Human WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1(WFIKKN1) ELISA kit

Code CSB-EL026098HU
Size 96T,5×96T,10×96T
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Product Details

Target Name
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Alternative Names
WFIKKN1 ELISA Kit; C16orf12 ELISA Kit; GASP2 ELISA Kit; WFIKKN ELISA Kit; PSEC0040 ELISA Kit; WAP ELISA Kit; Kazal ELISA Kit; immunoglobulin ELISA Kit; Kunitz and NTR domain-containing protein 1 ELISA Kit; Growth and differentiation factor-associated serum protein 2 ELISA Kit; GASP-2 ELISA Kit; hGASP-2 ELISA Kit; WAP ELISA Kit; follistatin ELISA Kit; immunoglobulin ELISA Kit; Kunitz and NTR domain-containing protein ELISA Kit
Abbreviation
WFIKKN1
Uniprot No.
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
0.312 ng/mL-20 ng/mL
Sensitivity
0.078 ng/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Cell Biology
Assay Principle
quantitative
Measurement
Sandwich
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human WFIKKN1 ELISA Kit was designed for the quantitative measurement of Human WFIKKN1 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.312 ng/mL-20 ng/mL and the sensitivity is 0.078 ng/mL.

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Target Background

Function
(From Uniprot)
Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity.
Gene References into Functions
  1. In this review, we summarize current knowledge about the WFIKKN proteins and propose that they are "companion" proteins for various growth factors by providing localized and sustained presentation of TGFB proteins to their respective receptors, thus regulating the balance between the activation of Smad and non-Smad pathways by TGFB. PMID: 27325460
  2. Data show that the KKN1 fragment generated by BMP1-cleavage of WFIKKN1 protein contributes most significantly to the observed enhancer activity. PMID: 27782377
  3. Data suggest that myostatin binding to its receptor (activin receptors type II) can be blocked by WFIKKN1 but not WFIKKN2; various forms of myostatin (promyostatin, myostatin pro-domain, and latent/processed myostatin) bind WFIKKN1 but not WFIKKN2. PMID: 23829672
  4. data indicate that WFIKKN proteins are antagonists of GDF8 and GDF11, but in the case of TGFbeta1, BMP2 and BMP4 they function as growth factor binding proteins PMID: 21054789
  5. Newly discovered WFIKKNPR gene structure and tissue distribution of gene expression is commpared with that of the WFIKKN gene in adult and fetal tissues and organs. PMID: 11928817
  6. Data suggest that the physiological target of WFIKKN protein may be trypsin. PMID: 12709070
  7. three-dimensional structure of a Kunitz domain with a tryptophan residue at the P02 site of the protease-recognition loop PMID: 16791741
  8. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. PMID: 18596030

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Subcellular Location
Secreted.
Protein Families
WFIKKN family
Tissue Specificity
Expressed in pancreas, kidney, liver, placenta, and lung.
Database Links

HGNC: 30912

OMIM: 608021

KEGG: hsa:117166

STRING: 9606.ENSP00000324763

UniGene: Hs.345818

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