Mouse Delta-like protein 4(DLL4) ELISA kit

1. anti-Dll4 antibody could inhibit the differentiation of Th17 cells in asthmatic mice. PMID: 28812183
2. Data suggest that endothelial specific Delta-like 4 (Dll4) overexpression appears as a promising anti-angiogenic modality that might improve cancer control. PMID: 28288569
3. Dll4 seems to promote Apc (Min/+) tumorigenesis. PMID: 28086833
4. Dll4-Notch1 signalling couples sprouting angiogenesis and artery formation. PMID: 28714968
5. Results suggest that Dll4 activation during differentiation sustained Treg cell phenotype and function to control respiratory syncytial virus infection. PMID: 28077598
6. DLL4 expression is not associated with the Pathogenesis of Non-Alcoholic Steatohepatitis. PMID: 27898698
7. Dll4 modulates liver inflammatory response by down-regulating chemokine expression PMID: 27171900
8. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling PMID: 26870802
9. miRNA-30e targeted the 3'-UTR of Dll4 and downregulated Dll4 expression PMID: 26786283
10. Dll4/Notch signaling and HIF-1alpha are closely related to lymphangiogenesis in dry eye-induced lacrimal glands. PMID: 26828208
11. Dll4-induced Notch1 activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region. PMID: 26465397
12. Tumor promoting effect of low-dosage inhibition needs to be considered when implementing Delta-like 4 targeting therapies. PMID: 26314892
13. The heart defects in Dll4-/- embryos are consistent with primary defects in vessel patterning. PMID: 26340748
14. DLL4 is an efficient cis-inhibitor of Notch signaling during embryogenesis. PMID: 26114479
15. Macrophage Dll4 promotes lesion development in vein grafts via macrophage activation and crosstalk between macrophages and smooth muscle cells. PMID: 26404485
16. work reveals how lymphatic vessel responses are shaped by tissue specialization and uncover a role for continuous DLL4 signaling in the function of adult lymphatic vasculature. PMID: 26529256
17. Delta-like 4-mediated Notch signaling is required for early T-cell development in a three-dimensional thymic structure. PMID: 25976373
18. a reduction of mechanical force near the boundary promotes Notch1-Dll4 signalling to dynamically regulate the density of leader cells during collective cell migration PMID: 25766473
19. selective expression of Dll4 in progenitors/precursors contributes to its functional specificity in neuronal specification and that the Dll4-Cre line is a valuable tool for gene manipulation to study Notch signaling. PMID: 25179941
20. The Notch ligand DLL4 is abundantly expressed on bone marrow Ocn(+) cells, and selective depletion of DLL4 from these cells recapitulated the thymopoietic abnormality PMID: 25918341
21. CCM1- and CCM3-silenced endothelial cells have a reduced expression of the Notch ligand Delta-like 4 (DLL4) resulting in impaired Notch signaling PMID: 25791711
22. Data indicate that systemic delta-like 1 protein Dll1/delta-like4 protein Dll4 inhibition decreased T cell cytokines and graft infiltration. PMID: 25687759
23. Dll4 plays a key role in regulating decidual angiogenesis and related pregnancy through induction of a tip/stalk phenotype. PMID: 24780197
24. Data show that one mechanism by which sex steroids influence thymopoiesis is through direct inhibition in cortical thymic epithelial cells (cTECs) of Delta-like 4 (Dll4), a Notch ligand crucial for the commitment and differentiation of T cell progenitors. PMID: 25332287
25. study demonstrates activity-dependent reduction of DLL4 expression and proteolytic cleavage of Notch3 in the hypothalamic-neurohypophysial system. PMID: 24943269
26. Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells. PMID: 24386421
27. Demonstrate that the action of IFNgamma on endothelial cellss, but not other cells, is highly effective for tumour angiostasis, which involves down-regulating Dll4. PMID: 24615277
28. Dll4/Notch signaling in tumor cells magnified TGF-beta-induced pSMAD2/3 signaling and was required to sustain TGF-beta-induced tumor cell growth PMID: 24520074
29. The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated in the mouse testis PMID: 24015274
30. We provide evidence that BMP/TGFbeta signaling is activated in V2b precursors and that Dll4-mediated Notch signaling is responsible for this activation. PMID: 24257627
31. DL4-mediated Notch signaling is essential for the development of both alphabeta and gammadelta T-cell lineages in the embryo. PMID: 23881845
32. The Dll4/Notch-1 signaling pathway has a modulatory role in VEGF-dependent luteal angiogenesis and related function through induction of a tip/stalk phenotype. PMID: 24074756
33. Hypoxia upregulates expression of the Notch ligand Dll4 and increases Notch signaling in a process requiring the vasoactive hormone adrenomedullin. PMID: 23379656
34. Overexpression of miR-126 results in the upregulation of VEGF, bFGF and Notch ligand Dll4 in the mesenchymal stem cells. PMID: 23229021
35. Data indicate that expression of Dll4 is specific to theca layer endothelial cells (ECs); Notch1/Notch4 in theca layer ECs and vascular smooth muscle cells (VSMCs), Notch3 is restricted to VSMCs; Notch2 in granulosa cells (GCs) of small follicles. PMID: 23675950
36. Vegf signaling activates MAP kinase (MAPK)-dependent E26 transformation-specific sequence factors in the arterial endothelium to drive expression of Dll4 and Notch4. PMID: 23830865
37. Arterial Dll4 expression requires the direct binding of both the RBPJ/Notch intracellular domain and SOXF transcription factors. PMID: 23818617
38. expression induced by VEGF-A in adult endothelial cells PMID: 23394931
39. The present study focused on the effects of systemic anti-Dll4 targeting in the bone marrow (BM) microenvironment. PMID: 23285048
40. Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. PMID: 23533173
41. endothelium, via Dll4 and PDGF-BB, induces a fate switch in adjacent skeletal myoblasts PMID: 23477786
42. sDLL4/28-525 inhibited CNV in C57Bl6 and its effect was reversed by a gamma-secretase inhibitor that blocks Notch signaling PMID: 22869002
43. Data show that Notch1/Dll4-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment. PMID: 23134786
44. delta-like 4 (Dll4) function relies on a combination of factors, which include strong Mindbomb1 (Mib1) association ubiquitination, and internalization and recycling back to the cell surface, to engage Notch1 effectively. PMID: 23162128
45. Dll4 skewed macrophages toward a proinflammatory phenotype ("M1"). These results suggest that Dll4-Notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders. PMID: 22699504
46. This study highlights a role for Dll4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis. PMID: 22514637
47. Anti-Dll4 treatment reverses established type 1 diabetes (T1D)and fully prevents T1D via a T(reg) cell-mediated mechanism and inhibits CD8(+) T cell pancreatic islet infiltration. PMID: 22547652
48. Data show that that inhibition of Dll4/Notch signaling causes improved vascular function and accelerated wound healing. PMID: 22279550
49. The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis. PMID: 22364862
50. Dll4 is directly activated by Foxn4 via phylogenetically conserved enhancers. Dll4 can partly mediate the Foxn4 function by serving as a major Notch ligand to expand the progenitor pool and limit photoreceptor production. PMID: 22323600

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KEGG: mmu:54485

STRING: 10090.ENSMUSP00000099575

UniGene: Mm.143719