CAPN6 Antibody, HRP conjugated

Code CSB-PA897594LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CAPN6 Polyclonal antibody
Uniprot No.
Target Names
CAPN6
Alternative Names
CALP M antibody; Calpain-6 antibody; Calpain-like protease X-linked antibody; Calpamodulin antibody; CalpM antibody; CAN6_HUMAN antibody; CANP X antibody; CANPX antibody; CAPN 6 antibody; Capn6 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Calpain-6 protein (195-494AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.
Gene References into Functions
  1. High CAPN6 expression is associated with liver cancer. PMID: 26375440
  2. CAPN6 promotes atherogenicity in inflamed macrophages by disturbing CWC22/EJC systems. PMID: 27525442
  3. syndecan-2 exerts its pro-apoptotic function through modulation of the endothelin-1/NFkappaB signaling and through downregulation of calpain-6. PMID: 21681744
  4. results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis PMID: 18657900
Subcellular Location
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
Protein Families
Peptidase C2 family
Tissue Specificity
Expressed only in placenta.
Database Links

HGNC: 1483

OMIM: 300146

KEGG: hsa:827

STRING: 9606.ENSP00000317214

UniGene: Hs.496593

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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