EDEM2 Antibody

Code CSB-PA861146LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA861146LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA861146LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EDEM2 Polyclonal antibody
Uniprot No.
Target Names
EDEM2
Alternative Names
bA4204.1 antibody; C20orf31 antibody; C20orf49 antibody; EDEM 2 antibody; EDEM2 antibody; EDEM2_HUMAN antibody; ER degradation enhancer mannosidase alpha like 2 antibody; ER degradation enhancing alpha mannosidase like 2 antibody; ER degradation enhancing alpha mannosidase like protein 2 antibody; ER degradation enhancing mannosidase like protein 2 antibody; ER degradation-enhancing alpha-mannosidase-like 2 antibody; FLJ10783 antibody; UNQ573/PRO1135 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human ER degradation-enhancing alpha-mannosidase-like protein 2 protein (22-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The EDEM2 Antibody (Product code: CSB-PA861146LA01HU) is Non-conjugated. For EDEM2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA861146LB01HU EDEM2 Antibody, HRP conjugated ELISA
FITC CSB-PA861146LC01HU EDEM2 Antibody, FITC conjugated
Biotin CSB-PA861146LD01HU EDEM2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.
Gene References into Functions
  1. EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog PMID: 24910992
  2. Glycoproteins mannose trimming from Man9GlcNAc2 to Man8GlcNAc2 is conducted mainly by EDEM2. PMID: 25092655
  3. Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in endoplasmic reticulum associated degradation. PMID: 15537790
  4. EDEM2 regulates endoplasmic reticulum-associated glycoprotein degradation PMID: 15579471
  5. Degrades misfolded alpha1-antitrypsin in the ER. PMID: 15537790

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Subcellular Location
Endoplasmic reticulum lumen.
Protein Families
Glycosyl hydrolase 47 family
Tissue Specificity
Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
Database Links

HGNC: 15877

OMIM: 610302

KEGG: hsa:55741

STRING: 9606.ENSP00000363616

UniGene: Hs.720177

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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