ISCA1 Antibody, HRP conjugated

1. the phenotype observed in all affected subjects with the ISCA1 pathogenic variant is similar to that previously described in all four types of multiple mitochondrial dysfunctions syndromes. PMID: 28356563
2. The structural plasticity of the dimeric state of the [2Fe-2S] bound form of human GRX5 is the crucial factor that allows an efficient cluster transfer to the partner proteins human ISCA1 and ISCA2 by a specific protein-protein recognition mechanism. PMID: 24733926
3. The data presented here show that the Isu1 suppressor mimics the frataxin effects on Nfs1, explaining the bypassing activity. PMID: 24217246
4. ISCA1, ISCA2, and IBA57 were depleted by RNA interference. Depleted cells contained massively swollen and enlarged mitochondria that were virtually devoid of cristae membranes, demonstrating the importance of these proteins for mitochondrial biogenesis. PMID: 22323289
5. Iron-binding activity of human iron-sulfur cluster assembly protein hIscA1 PMID: 20302570
6. screening a human brain cDNA expression library with serum from a patient suffering from the autoimmune Sjogren's syndrome yielded a gene product called hIscA implicated in iron-sulfur cluster biogenesis PMID: 15262227
7. Required for functional heme biosynthesis in erythroid cells. PMID: 19656490

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HGNC: 28660

OMIM: 611006

KEGG: hsa:81689

STRING: 9606.ENSP00000365159

UniGene: Hs.449291