NDST1 Antibody

Code CSB-PA015614LA01HU
Size US$166
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  • Western blot
    All lanes: NDST1 antibody at 6µg/ml + MCF-7 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 101, 63 kDa
    Observed band size: 85 kDa

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA015614LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA015614LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NDST1 Polyclonal antibody
Uniprot No.
Target Names
NDST1
Alternative Names
NDST1 antibody; HSST antibody; HSST1 antibody; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 antibody; EC 2.8.2.8 antibody; Glucosaminyl N-deacetylase/N-sulfotransferase 1 antibody; NDST-1 antibody; N-heparan sulfate sulfotransferase 1 antibody; N-HSST 1 antibody; [Heparan sulfate]-glucosamine N-sulfotransferase 1 antibody; HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 antibody; EC 3.-.-.-); Heparan sulfate N-sulfotransferase 1 antibody; EC 2.8.2.-)] antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 protein (40-556AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NDST1 Antibody (Product code: CSB-PA015614LA01HU) is Non-conjugated. For NDST1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA015614LB01HU NDST1 Antibody, HRP conjugated ELISA
FITC CSB-PA015614LC01HU NDST1 Antibody, FITC conjugated
Biotin CSB-PA015614LD01HU NDST1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response. Required for the exosomal release of SDCBP, CD63 and syndecan.
Gene References into Functions
  1. Compound heterozygous mutations in NDST1 were identified, in the heparan sulfate N deacetylatase domain of one allele and the sulfotransferase domain of the other allele. This report expands the phenotypic spectrum of Ndst1 deficiency in humans. PMID: 28211985
  2. Among the genes enriched in this screening, the authors found that TM9SF2 is critical for N-sulfation of heparan sulfate and therefore for chikungunya virus infection because it is involved in the proper localization and stability of NDST1. PMID: 28404855
  3. Our data confirm NDST1 mutations as a cause of autosomal recessive intellectual disability with a distinctive phenotype, and support an important function of NDST1 in human development. PMID: 25125150
  4. demonstrate the essential role of domain cooperation within NDST-1 in producing HS with specific domain structures PMID: 26109066
  5. Upregulation of NDST1 is associated with chemoresistance in breast cancer. PMID: 25156775
  6. These findings establish NDST1 as a target of miR-24 and demonstrate how such NDST1 suppression in endothelial cells results in reduced responsiveness to VEGFA PMID: 23884416
  7. MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803 PMID: 21947487
  8. Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1. PMID: 20129923
  9. Altered expression of NDST-1 mRNA in glomerular basement membrane in puromycin aminonucleoside nephrosis. PMID: 14966466
  10. effect of targeted inactivation of the Ndst1 gene on the inflammatory response associated with allergic inflammation PMID: 19710461
  11. the expression of the NDST-1 isoform was approximately equal at all stages of mast cell maturation PMID: 19915053

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Involvement in disease
Mental retardation, autosomal recessive 46 (MRT46)
Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein Families
Sulfotransferase 1 family, NDST subfamily
Tissue Specificity
Widely expressed. Expression is most abundant in heart, liver and pancreas.
Database Links

HGNC: 7680

OMIM: 600853

KEGG: hsa:3340

STRING: 9606.ENSP00000261797

UniGene: Hs.222055

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