MOK Antibody

Datasheet

Code	CSB-PA775498
Size	US$295
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Image	Western blot analysis on HepG2 cell lysate using RAGE Antibody
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MOK Polyclonal antibody

Uniprot No.

Q9UQ07

Target Names

MOK

Alternative Names

Antigen recognized by autologous cytolytic T lymphocytes antibody; EC 2.7.11.22 antibody; LE 9211 A antigen antibody; MAPK/MAK/MRK overlapping kinase antibody; MOK antibody; MOK protein kinase antibody; MOK_HUMAN antibody; RAGE 1 antibody; RAGE antibody; RAGE-1 antibody; RAGE1 antibody; Renal cell carcinoma antigen (MOK protein kinase) antibody; Renal tumor antigen 1 antibody; Renal tumor antigen antibody; STK30 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

A synthesized peptide derived from Human RAGE

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.

Gene References into Functions

our results suggest MOK promoter hypomethylation is a common event and contributes to MOK overexpression in acute myeloid leukemia PMID: 25755699
The findings indicate a statistically significant association of p.Gly82Ser polymorphism in RAGE with DR in T2DM patients. PMID: 24529564
the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
Our results suggest that RAGE may be important in tumor invasion and could be a potential predictor for the prognosis of hepatocellular carcinoma patients. PMID: 21717246
PBMNC from type 2 diabetics were more sensitive to innate immune stimulation with LPS and monoclonal agonist anti-TLR4 than were cells from ND. The actions of LPS, anti-TLR4 and anti-RAGE potentiated the production of IL-6 and TNF-alpha in both groups. PMID: 21377387
The RAGE pathway may play an important role in STAT3 induction in glioma-associated macrophages and microglia, a process that may be mediated through S100B. PMID: 21264954
RAGE was demonstrated in all 8 yolk sac tumors and 21 of 26 embryonal carcinomas. In yolk sac tumors, RAGE reactivity was diffusely present throughout the tumors. In embryonal carcinomas, RAGE was identified only in yolk sac components PMID: 12777992
identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2 PMID: 15327990
May provide suitable targets for immunotherapy of renal cell carcinoma. PMID: 15900605
Compared RAGE and PAX-2 staining in metastatic clear renal cell carcinoma. PMID: 18685487
POLL is under genetic selection in Sub-Saharan African populations. PMID: 19060005

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Subcellular Location

Cytoplasm. Cell projection, cilium. Nucleus.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

Tissue Specificity

Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.

Database Links

HGNC: 9833

OMIM: 605762

KEGG: hsa:5891

STRING: 9606.ENSP00000355304

UniGene: Hs.104119

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