RPA4 Antibody

Datasheet

Code	CSB-PA622640ESR2HU
Size	US$166
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Image	Western blot All lanes: RPA4 antibody at 3μg/ml Lane 1: K562 whole cell lysate Lane 2: Mouse spleen tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 29 kDa Observed band size: 29 kDa Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA622640ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RPA4 Polyclonal antibody

Uniprot No.

Q13156

Target Names

RPA4

Alternative Names

HSU24186 antibody; MGC120333 antibody; MGC120334 antibody; p30 antibody; Replication factor A protein 4 antibody; Replication protein A 30 kDa subunit antibody; RF A antibody; RF-A protein 4 antibody; RFA antibody; RFA4_HUMAN antibody; RP A antibody; RP-A p30 antibody; RPA antibody; RPA4 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Replication protein A 30 kDa subunit protein (1-230AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.

Gene References into Functions

Findings provide the first direct evidence for the function of alternative form of RPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells. PMID: 19996105
Results suggest that RPA4 cannot support cell proliferation but can support processes that maintain the genomic integrity of the cell. PMID: 19942684
Hyperphosphorylated replication protein A is preferentially localized to double-stranded break repair and the DNA damage checkpoint complexes in response to DNA damage. PMID: 15929725

Subcellular Location

Nucleus. Note=Localizes to DNA repair foci after DNA damage.

Protein Families

Replication factor A protein 2 family

Tissue Specificity

Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels.

Database Links

HGNC: 30305

OMIM: 300767

KEGG: hsa:29935

STRING: 9606.ENSP00000362131

UniGene: Hs.659349

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

DNA repair pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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