RXRG Antibody

Code CSB-PA020614GA01HU
Size $600
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
RXRG
Alternative Names
MGC109416 antibody; NR2B3 antibody; Nuclear receptor subfamily 2 group B member 3 antibody; OTTHUMP00000060418 antibody; Retanoic X receptor gamma antibody; Retinoic acid receptor RXR gamma antibody; Retinoic acid receptor RXR-gamma antibody; Retinoid X receptor gamma antibody; RXR G antibody; RXR gamma antibody; RXRC antibody; Rxrg antibody; RXRG_HUMAN antibody; RXRgamma antibody
Species Reactivity
Human,Mouse,Rat
Immunogen
Human RXRG
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid.
Gene References into Functions
  1. genetic association studies in a population in Brazil: Data suggest that SNPs in RXRG (rs2134095) and GC (rs7041) are associated with low-density lipoprotein cholesterol levels and hypercholesterolemia in the population studied; there was no apparent association with an SNP in VDR (rs2228570). (RXRG = retinoid X receptor gamma; GC = vitamin D-binding protein; VDR = vitamin D receptor) PMID: 27721113
  2. Germline mutations in the RXRG gene are linked to Familial isolated pituitary adenoma in a Brazilian Family. PMID: 27245436
  3. Data show that some rexinoids display selective coactivator (CoA) recruitment by the retinoid X receptors (RXRs) homodimer and by the heterodimers nuclear receptor Nur77/RXR and Nurr1/RXR. PMID: 26148973
  4. loss of RXR-gamma levels appears to provide mechanistic benefits to transformed cells towards the acquisition of resistance to apoptosis hallmark of cancer PMID: 23936423
  5. Genetic variation in RXRgamma gene may contribute to the development of HIVLD in combination antiretroviral therapy treated HIV patients. PMID: 23759678
  6. The RXR-gamma rs3818569 single nucleotide polymorphisms is associated with diabetic retinopathy development in the Taiwanese population. PMID: 22180072
  7. results indicate that RXR-gamma is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination. PMID: 21131950
  8. methylation-associated downregulation of the RXRG gene may play a differential role in the carcinogenesis of non-small cell lung cancer (NSCLC) according to smoking status. PMID: 20113835
  9. Single nucleotide polymorphism not a factor in resistance to thyroid hormone. PMID: 15186611
  10. The retinoid X receptor, gamma expression is mainly restricted to the muscle and brain. PMID: 15608692
  11. These results show that the stimulation of ASCT2 expression in response to glutamine in part involves binding of FXR/RXR to the ASCT2 promoter. PMID: 16197915
  12. RXRgamma contributes to the genetic background of familial combined hyperlipidemia. PMID: 17272748

Show More

Hide All

Subcellular Location
Nucleus. Cytoplasm.
Protein Families
Nuclear hormone receptor family, NR2 subfamily
Tissue Specificity
Expressed in aortic endothelial cells (at protein level).
Database Links

HGNC: 10479

OMIM: 180247

KEGG: hsa:6258

STRING: 9606.ENSP00000352900

UniGene: Hs.26550

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*