DEDD2 Antibody

Code CSB-PA837874ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA837874ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA837874ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DEDD2 Polyclonal antibody
Uniprot No.
Target Names
DEDD2
Alternative Names
DEDD2 antibody; FLAME3 antibody; PSEC0004DNA-binding death effector domain-containing protein 2 antibody; DED-containing protein FLAME-3 antibody; FADD-like anti-apoptotic molecule 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DNA-binding death effector domain-containing protein 2 protein (1-240AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Gene References into Functions
  1. FLAME-3 forms nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC PMID: 11965497
  2. DEDD and DEDD2 may be important mediators for death receptors and that they may target caspases to the nucleus. PMID: 12527898
Subcellular Location
Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
Tissue Specificity
Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell l
Database Links

HGNC: 24450

KEGG: hsa:162989

STRING: 9606.ENSP00000470082

UniGene: Hs.515432

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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