IL25 Antibody

Code CSB-PA875653ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA875653ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IL25 Polyclonal antibody
Uniprot No.
Target Names
IL25
Alternative Names
IL 17E antibody; IL 25 antibody; IL-17E antibody; IL-25 antibody; IL17e antibody; IL25 antibody; IL25_HUMAN antibody; Interleukin 17E antibody; Interleukin 25 antibody; Interleukin-17E antibody; Interleukin-25 antibody; Interleukin17E antibody; Interleukin25 antibody; OTTHUMP00000027946 antibody; OTTHUMP00000246238 antibody; UNQ3120/PRO10272 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Interleukin-25 protein (33-177AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
Gene References into Functions
  1. this review details the structural characteristics, expression patterns, responder cells, biological properties, and role of IL-25 in disease pathogenesis PMID: 30345318
  2. this study shows that IL-25 reduces Th17 cells and inflammatory responses in human peripheral blood mononuclear cells PMID: 29966691
  3. Endometrial stromal cells differentiate into decidual stromal cells in the presence of ovarian hormones, resulting in the upregulation of IL25/IL17RB expression in endometrial stromal cells. PMID: 29257317
  4. In conclusion, the findings of the present study suggest that IL-25 but not IL-33 might contribute to the pathogenesis of chronic eosinophilic inflammation of the lung in patients with CEP. PMID: 28875265
  5. Nasal Il-25 is overexpressed in patients with chronic rhinosinusitis with nasal polyps and airway hypersensitiveness. PMID: 28870448
  6. IL-25-induced activation of nasal fibroblast and its association with the remodeling of chronic rhinosinusitis with nasal polyposis PMID: 28771607
  7. The authors concluded that IL-25 provides protection from amebiasis, which is dependent upon intestinal eosinophils and suppression of TNF-alpha. PMID: 28246365
  8. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung. PMID: 27909985
  9. Our findings suggest that the IL-25/IL-25R axis may play an important role in promoting the recruitment and proinflammatory function of eosinophils in allergic asthma. PMID: 27685606
  10. Chronic rhinosinusitis with nasal polyps (CRSwNP) epithelial cells release TSLP and IL-25 when stimulated by poly(I:C) but not by DP or AF, suggesting that viral infection may contribute to maintain and amplify the T2 immune response seen in CRSwNP. PMID: 28127565
  11. Increased induction and expression of TSLP, IL-25, and IL-33 from nasal epithelial cells contribute to the pathophysiology of eosinophilic chronic rhinosinusitis. PMID: 26540312
  12. Women with endometriosis showed significantly higher levels of IL-25 in their PF (p=0.019) compared to controls. IL-25 levels did not correlate with the stage of endometriosis. PMID: 26852387
  13. IL-8 and IL-25 are targets of miR-20b. PMID: 26845056
  14. Our findings indicate that the alarmin cytokines IL-33 and IL-25 increase basophil activation and migratory potential, and may pose as a novel therapeutic targets for the treatment of allergic asthma. PMID: 26762527
  15. The IL17E rs79877597 SNP was a modifier of the risk for psoriasis disease severity and psoriatic arthritis. PMID: 26347322
  16. Findings indicate that the release of interleukin 25 (IL-25) from tumour-associated fibroblasts (TAFs) may serve as a check point for control of mammary tumour metastasis. PMID: 27089063
  17. IL-25 upregulated PD-L1 surface expression through the signaling pathways of JNK and STAT3, with STAT3 found to constitutively occupy the proximal region of the PD-L1 promoter. PMID: 26321145
  18. we have demonstrated that the expression of ET-1 and IL-25 was coordinately upregulated in the lesional keratinocytes of patients with AD and a murine AD model. PMID: 25903653
  19. IL-25 overexpression was observed in eosinophilic chronic rhinosinusitis and may serve as a mediator of eosinophilic CRS. PMID: 25975248
  20. expression of immunoreactivity for IL-17A, IL-17RA, IL-17E, and IL-17F was significantly elevated in prostatic tissue from benign prostatic hyperplasia and prostate cancer compared with that in controls PMID: 26356122
  21. This article focuses on evidence for the role of IL-25, IL-33 and TSLP in human allergic disease; although this triad of cytokines is described as epithelial derived, it is clear that their expression within lung tissue is much more widespread.[Review] PMID: 25705788
  22. The levels of mRNA for IL-25 were not significantly elevated in parotid gland tissues from Kimura Disease patients as compared to controls. PMID: 25676453
  23. asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro-type 2 cytokine in response to a viral infection, and IL-25 is a key mediator of RV-induced exacerbations of pulmonary inflammation PMID: 25273095
  24. increased levels in patients with chronic rhinosinusitis with nasal polyps PMID: 25704964
  25. Because IL-25 has a major role in triggering type 2 responses, bronchial epithelial IL-25 expression is likely a key determinant of type 2 response activation in asthma PMID: 25133876
  26. Human chorionic gonadotropin up-regulates Il25, promoting the proliferation of decidual stromal cells by activation of JNK and AKT signal pathways. PMID: 24746746
  27. Patients with the 'IL-5, IL-17A, IL-25-high' airway inflammatory pattern are often uncontrolled asthmatics, despite daily treatment. PMID: 23957336
  28. IL-25 and type 2 innate lymphoid cells have roles in development of pulmonary fibrosis PMID: 24344271
  29. IL-25 expression is markedly reduced during human and experimental fulminant hepatitis. PMID: 23564603
  30. IL-25 and IL-33-driven type-2 innate lymphoid cells have roles in atopic dermatitis PMID: 24323357
  31. IL-25 enhances herpes simplex virus (HSV)-1 and vaccinia virus replication by inhibiting filaggrin expression, and IL-25 acts synergistically with IL-4 and IL-13 to enhance HSV-1 replication in vitro PMID: 23657503
  32. Suggest that IL-25 production by airway epithelial cells is regulated by the transcription and protein release levels and that allergen proteases likely play pivotal roles in both biological processes. PMID: 23590308
  33. Our data demonstrate that IL-33 plays a critical role in the rapid induction of airway contraction by stimulating the prompt expansion of IL-13-producing type 2 innate lymphoid cells, whereas IL-25-induced responses are slower and less potent. PMID: 23810766
  34. IL-25 Is Decreased in Sera of Patients With inflammatory bowel disease. PMID: 23429464
  35. IL-25 secreted from epithelial cells has the potential to promote airway remodeling in asthma. PMID: 22691357
  36. We observed significant downregulation of IL-25 in women with recurrent miscarriage compared with controls. PMID: 22266274
  37. IL-25 production is differently regulated by TNF-alpha and TGF-beta1 in the human g PMID: 20944558
  38. production is linked to the amount of specific IgE antibodies in blood samples of 6 yr old children in Germany PMID: 20492545
  39. Findings suggest that IL-25 is elevated in asthma and contributes to angiogenesis. PMID: 21205894
  40. IL-25 may have a role in atopic dermatitis PMID: 20861853
  41. Eosinophils are the main source of IL-25, whereas activated CD4+ memory T cells are the IL-17RB-expressing cells in Churg-Strauss syndrome. PMID: 20729468
  42. IL-17A and IL-25 had opposing effects on thymic stromal lymphopoietin regulation in human nasal epithelial cells PMID: 19968632
  43. Overexpression of IL-17E up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. PMID: 11714825
  44. Transgenic overexpression from humans into mice results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. PMID: 12239140
  45. IL-17E may contribute to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts. This supports a role for IL-17E in asthma pathophysiology. PMID: 16522458
  46. IL-25 acts by amplifying TH2 cell-mediated allergic airway inflammation. IL-25 itself does not significantly induce allergic inflammation in vivo. PMID: 16950278
  47. IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells PMID: 17635955
  48. The upregulation of costimulation-induced IL-25 receptors and release of cytokines and chemokines from IL-25 treated costimulated Th cells were differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. PMID: 17719653
  49. Blocking IL-25 in an experimental model of allergic asthma prevents airway hyperresponsiveness, a critical feature of clinical asthma. PMID: 17889290
  50. Higher expressions of IL-17E, IL-17A, IL-17BR and IL-17R are associated with oral inflammation. PMID: 19095584

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Subcellular Location
Secreted.
Protein Families
IL-17 family
Tissue Specificity
Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
Database Links

HGNC: 13765

OMIM: 605658

KEGG: hsa:64806

STRING: 9606.ENSP00000328111

UniGene: Hs.302036

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