RAB18 Antibody

Code CSB-PA019165GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RAB18
Alternative Names
AA959686 antibody; RAB18 antibody; RAB18 small GTPase antibody; RAB18; member RAS oncogene family antibody; RAB18_HUMAN antibody; RAB18LI1 antibody; Ras related protein Rab 18 antibody; Ras-asssociated protein RAB18 antibody; Ras-related protein Rab-18 antibody; RP11-148B2.1 antibody; WARBM3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human RAB18
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.
Gene References into Functions
  1. The authors found that the previously documented interaction between TRAPPII and COPI was also required for the recruitment of Rab18 to the lipid droplet. PMID: 28003315
  2. findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people. PMID: 24996981
  3. RAB18 is the direct target of miR-455-5p in gastric cancer. PMID: 27451075
  4. Warburg Micro syndrome is caused by RAB18 deficiency. PMID: 26063829
  5. These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets. PMID: 24997429
  6. High RAB18 expression is associated with glioma. PMID: 24477653
  7. Rab18-mediated membrane trafficking of FASN and NS3 facilitates dengue virus replication. PMID: 24696471
  8. Rab18 interacts with the HCV nonstructural protein NS5A. PMID: 23935497
  9. Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18. PMID: 23471881
  10. Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2. [Review] PMID: 23176487
  11. performed autozygosity mapping in five consanguineous families with Warburg micro syndrome without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18 PMID: 21473985
  12. Rab18 regulates lipid droplet-associated membrane formation PMID: 15914536
  13. analysis of a novel splice variant of human Rab18 gene PMID: 16147880
  14. Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion. PMID: 18349058
  15. Rab18 and Rab43 have key roles in ER-Golgi trafficking. PMID: 18664496
  16. Rab18 is recruited to lipid droplets during lipolysis PMID: 16207721

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Involvement in disease
Warburg micro syndrome 3 (WARBM3)
Subcellular Location
Apical cell membrane. Lipid droplet.
Protein Families
Small GTPase superfamily, Rab family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 14244

OMIM: 602207

KEGG: hsa:22931

STRING: 9606.ENSP00000349415

UniGene: Hs.406799

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