SEPSECS Antibody

Code CSB-PA021019GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SEPSECS
Alternative Names
DKFZp434B1417 antibody; Liver pancreas antigen antibody; Liver-pancreas antigen antibody; LP antibody; MGC161491 antibody; O phosphoseryl tRNA(Sec) selenium transferase antibody; O-phosphoseryl-tRNA(Sec) selenium transferase antibody; Sec synthase antibody; Selenocysteine synthase antibody; Selenocysteinyl tRNA(Sec) synthase antibody; Selenocysteinyl-tRNA(Sec) synthase antibody; Sep (O phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase antibody; Sep tRNA:Sec tRNA synthase antibody; Sep-tRNA:Sec-tRNA synthase antibody; SepSecS antibody; SLA antibody; SLA p35 antibody; SLA-p35 antibody; SLA/LP antibody; SLA/LP autoantigen antibody; Soluble liver antigen antibody; Soluble liver antigen/liver pancreas antigen antibody; Soluble Liver/Pancreas Antigen antibody; SPCS_HUMAN antibody; tRNA(Ser/Sec) associated antigenic protein antibody; tRNA(Ser/Sec)-associated antigenic protein antibody; TRNP48 antibody; UGA suppressor tRNA associated protein antibody; UGA suppressor tRNA-associated protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SEPSECS
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Gene References into Functions
  1. Structural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase has been described. PMID: 27576344
  2. Epileptic encephalopathy with burst suppression without brain malformations is associated with pathogenic variation in SEPSECS. PMID: 28133863
  3. The progression of clinical symptoms in these families is evidently slower than in previously reported cases, and the cerebellar atrophy milder by brain MRI, indicating that SEPSECS mutations are also involved in milder late-onset cerebellar atrophy. PMID: 26888482
  4. results suggest SEPSECS as a candidate gene for progressive encephalopathies with lactate elevation. PMID: 26115735
  5. structural analysis of the terminal catalytic complex in selenocysteine synthesis PMID: 25190812
  6. Data suggest SEPSECS silencing in placental trophoblasts inhibits proliferation, induces apoptosis, and reduces production of progesterone/chorionic gonadotropin (P/hCG); SEPSECS over-expression promotes cell proliferation and secretion of P/hCG. PMID: 23966103
  7. The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. PMID: 20623998
  8. SepSecS mutations cause autosomal-recessive progressive cerebellocerebral atrophy in Jews of Iraqi and Moroccan ancestry. PMID: 20920667
  9. detectable in liver extracts of autoimmune hepatitis patients' cells as the major autoantigenic component PMID: 19683415
  10. crystal structure of tRNA(Sec) in complex with SepSecS, phosphoserine, and thiophosphate, together with in vivo and in vitro enzyme assays, supports a pyridoxal phosphate-dependent mechanism of Sec-tRNA(Sec) formation PMID: 19608919

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Involvement in disease
Pontocerebellar hypoplasia 2D (PCH2D)
Subcellular Location
Cytoplasm.
Protein Families
SepSecS family
Tissue Specificity
Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.
Database Links

HGNC: 30605

OMIM: 613009

KEGG: hsa:51091

STRING: 9606.ENSP00000371535

UniGene: Hs.253305

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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