SPAG11A Antibody

Code CSB-PA022460GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SPAG11A
Alternative Names
SPAG11A antibody; EP2 antibody; HE2 antibody; Sperm-associated antigen 11A antibody; Human epididymis-specific protein 2 antibody; He2 antibody; Protein EP2 antibody; Sperm antigen HE2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human SPAG11A
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May have antimicrobial activity. May also play a role sperm maturation, storage, and protection.
Gene References into Functions
  1. we report the three dimensional structure of the human SPAG11B proteins and their C-terminal peptides. web-based hydropathy, amphipathicity, and topology (WHAT) analyses and grand average of hydropathy PMID: 25573789
  2. Isoform C of SPAG11B encodes a peptide with antimicrobial activity against E. coli. PMID: 16411022
  3. Combination of two proteins, SPAG11B and TEX101, can be used for differential diagnosis of azoospermia PMID: 21933954
  4. SPAG11B/D is both a substrate and a potent inhibitor of TPSAB1 activity. PMID: 19535787
  5. HE2 peptides were detected in human epididymal epithelium, epididymal fluid, and ejaculate PMID: 12193388
  6. HE2 transcriptional and translational products normally expressed in the caput epididymidis were not affected by vasectomy. PMID: 14662784
  7. EP2 expression is more widespread in male reproductive tract than realized previously. Activity of every EP2 variant tested is antibacterial. Further investigation may reveal additional roles for EP2 peptides in primate male reproductive tract. PMID: 15229135
  8. In the chimpanzee epididymis, several mRNA HE2/EP2 variants are produced. Of these, three cDNAs code for two different protein sequences that have a cysteine distribution characteristic for beta-defensins. PMID: 10819450
  9. The human HE2/EP2 gene is the fusion product of two ancestral beta-defensin genes. During its evolution, the gene has acquired additional exons whose inclusion produces new message variants that encode peptides unrelated to defensins. PMID: 11259252

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Subcellular Location
Secreted.
Protein Families
SPAG11 family
Database Links

HGNC: 33342

OMIM: 606560

KEGG: hsa:653423

STRING: 9606.ENSP00000381480

UniGene: Hs.2717

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