SUN5 Antibody

Code CSB-PA022465GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SUN5
Alternative Names
SUN5; SPAG4L; TSARG4; SUN domain-containing protein 5; Sad1 and UNC84 domain-containing protein 5; Sperm-associated antigen 4-like protein; Testis and spermatogenesis-related gene 4 protein
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SPAG4L
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope.
Gene References into Functions
  1. The contribution of SUN5 mutations to acephalic spermatozoa might not be as high as described previously. PMID: 29331481
  2. Results, together with those of the previous study, show that SUN5 is required for the formation of the sperm head-tail junction and male fertility. PMID: 28541472
  3. results demonstrate that biallelic SUN5 mutations cause male infertility due to autosomal-recessive acephalic spermatozoa syndrome PMID: 27640305
  4. SPAG4L may play an important role in the meiotic stage of spermatogenesis PMID: 21711156
Involvement in disease
Spermatogenic failure 16 (SPGF16)
Subcellular Location
Nucleus inner membrane; Single-pass membrane protein. Golgi apparatus.
Tissue Specificity
Sperm (at protein level). Widely expressed. Conflictingly shown to be specifically expressed in testis.
Database Links

HGNC: 16252

OMIM: 613942

KEGG: hsa:140732

STRING: 9606.ENSP00000348496

UniGene: Hs.375186

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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