SPATA2 Antibody

Code CSB-PA022496GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SPATA2
Alternative Names
FLJ13167 antibody; KIAA0757 antibody; PD 1 antibody; PD1 antibody; PPP1R145 antibody; Protein phosphatase 1 regulatory subunit 145 antibody; SPAT2_HUMAN antibody; SPATA 2 antibody; SPATA2 antibody; Spermatogenesis associated 2 antibody; Spermatogenesis associated PD1 antibody; Spermatogenesis associated protein 2 antibody; Spermatogenesis associated protein PD1 antibody; Spermatogenesis-associated protein 2 antibody; Spermatogenesis-associated protein PD1 antibody; Tamo antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SPATA2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD.
Gene References into Functions
  1. SPATA2 has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP and CYLD, thereby enabling recruitment of CYLD to signaling complexes. PMID: 27545878
  2. The data reveal SPATA2 as a high-affinity binding partner of CYLD and HOIP, and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB signaling. PMID: 27591049
  3. this study identifies SPATA2 as an important factor in the TNF signaling pathway with a substantial role for the effects mediated by the cytokine. PMID: 27458237
  4. The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes. PMID: 27307491
  5. The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population. PMID: 25264125
  6. PD-L1 is highly expressed in tumours rather than tumour-free lymph nodes, which is closely correlated with the impairment of IFN-gamma production of tumour-infiltrating T-cells. PMID: 25093496
  7. Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. PMID: 20385810
  8. cloning and base sequence of the promoter region PMID: 12531478
  9. disappearance of TLD epitope reactivity from an otherwise stable EBV-specific response reflects selective loss of cognate antigen restimulation, not IL-7-dependent signals, and is immediately preceded by PD-1 upregulation to unprecedented levels. PMID: 19605492

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
SPATA2 family
Tissue Specificity
Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level). Low expression in spleen, thymus and prostate.
Database Links

HGNC: 14681

OMIM: 607662

KEGG: hsa:9825

STRING: 9606.ENSP00000289431

UniGene: Hs.48513

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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