SQRDL Antibody

Datasheet

Code	CSB-PA022646GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9Y6N5

Target Names

SQOR

Alternative Names

0610039J17Rik antibody; 4930557M22Rik antibody; CGI 44 antibody; CGI44 antibody; mitochondrial antibody; PRO1975 antibody; SQRD_HUMAN antibody; Sqrdl antibody; Sulfide dehydrogenase like antibody; Sulfide quinone reductase like antibody; Sulfide quinone reductase-like (yeast) antibody; Sulfide:quinone oxidoreductase antibody; Sulfide:quinone oxidoreductase, mitochondrial antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human SQRDL

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.

Gene References into Functions

The evidence supported the significant role of SQRDL in the etiology of postmenopausal osteoporosis and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women. PMID: 29855663
Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone Oxidoreductase PMID: 26318450
Therefore, this study reveals the reduction in SQR activity as one of the pathomechanisms associated with Coenzyme Q deficiency syndrome. PMID: 27856619
Data, including data from studies using recombinant SQR immobilized by embedding in nanodiscs, suggest that immobilized SQR exhibits enhanced catalytic performance; pre-steady-state kinetic characterization of immobilized SQR catalytic cycle indicates that glutathione serves as physiologically relevant sulfur acceptor during hydrogen sulfide oxidation. PMID: 28512131
The I264T SQRDL polymorphism is associaated with osteoporosis in Korean postmenopausal women. PMID: 26258864
SQR is part of the human mitochondrial hydrogen sulfide oxidation pathway PMID: 25225291
Sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite. PMID: 22852582

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Subcellular Location

Mitochondrion.

Protein Families

SQRD family

Database Links

HGNC: 20390

OMIM: 617658

KEGG: hsa:58472

STRING: 9606.ENSP00000260324

UniGene: Hs.511251

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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