THOP1 Antibody

1. Data suggest that three new candidate genes involved in the development of rheumatoid arthritis (RA): ERBB2, TP53 and THOP1. PMID: 28148290
2. THOP1 may have clinical potentials to be employed as a promising biomarker to identify individuals with better prognosis and a novel antitumor agent for therapy of patients with NSCLC PMID: 25180910
3. Low THOP1 expression levels are associated with recurrence of hepatocellular carcinoma. PMID: 24604581
4. TCEP. Data indicate that THIMET-oligopeptidase (TOP) oxidation by H2O2 and high valence states of hemeproteins does not lead to enzyme oligomerization. PMID: 24223886
5. shear-dependent TOP induction down-regulates MHC1 levels, pointing to a role for TOP in the flow-mediated regulation of endothelial immunogenicity PMID: 23708739
6. The semi-quantitative intracellular peptidome analyses of siRNA-transfected HEK293 cells shows that the levels of specific intracellular peptides are either increased or decreased upon EP24.15 inhibition. PMID: 22796113
7. mediates antigen processing that generates cytotoxic T cell epitopes PMID: 21151101
8. human thimet oligopeptidase crystal structure shows substrate recognition, regulation, and localization PMID: 14998993
9. THIMET has a role in degradation of peptides generated by proteasomes PMID: 15328361
10. EP24.15 associates with AT1 and B2 receptors both at the plasma membrane and after receptor internalization PMID: 15376229
11. Mutations at only two residues (Glu-469 and Arg-498) are required to swap specificity with neurolysin, a result that is confirmed by testing the two-mutant constructs. PMID: 17251185
12. increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load. PMID: 18571100
13. Over 100 peptides were identified in human embryonic kidney 293 (HEK293) cells that are derived from intracellular proteins; many but not all of these peptides are substrates or products of EP24.15. PMID: 19282285
14. interaction between EP24.15 and calmodulin is regulated within cells and is important for the stimulated secretion of EP24.15 from HEK293 cells. PMID: 19614740

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HGNC: 11793

OMIM: 601117

KEGG: hsa:7064

STRING: 9606.ENSP00000304467

UniGene: Hs.78769