SF3B6 Antibody, HRP conjugated

Code CSB-PA897543LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SF3B6 Polyclonal antibody
Uniprot No.
Target Names
SF3B6
Alternative Names
Ht006 antibody; P14 antibody; PM14_HUMAN antibody; Pre mRNA branch site protein p14 antibody; Pre-mRNA branch site protein p14 antibody; SAP14 antibody; SF3B 14 kDa subunit antibody; SF3B14 antibody; SF3B14a antibody; Splicing factor 3B, 14 kDa subunit antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Splicing factor 3B subunit 6 protein (1-125AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.
Gene References into Functions
  1. the p14-RNA interaction screens charges on the backbone of the branch site during spliceosome assembly. PMID: 26784522
  2. determined the high resolution structure of a complex between SF3b14 and a peptide derived from SF3b155 and proposed a model for recognition of the pre-mRNA branch sequence adenosine. PMID: 16432215
Subcellular Location
Nucleus.
Protein Families
SF3B6 family
Database Links

HGNC: 30096

OMIM: 607835

KEGG: hsa:51639

STRING: 9606.ENSP00000233468

UniGene: Hs.177861

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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