TRIB3 Antibody

Code CSB-PA847220LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA847220LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA847220LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRIB3 Polyclonal antibody
Uniprot No.
Target Names
TRIB3
Alternative Names
C20orf97 antibody; Neuronal cell death inducible putative kinase antibody; Neuronal cell death-inducible putative kinase antibody; NIPK antibody; p65 interacting inhibitor of NF-kappaB antibody; p65-interacting inhibitor of NF-kappa-B antibody; SINK antibody; SKIP 3 antibody; SKIP3 antibody; TRB 3 antibody; TRB-3 antibody; TRB3 antibody; TRIB 3 antibody; Trib3 antibody; TRIB3_HUMAN antibody; Tribbles homolog 3 antibody; Tribbles pseudokinase 3 antibody; Tribbles3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tribbles homolog 3 protein (152-325AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TRIB3 Antibody (Product code: CSB-PA847220LA01HU) is Non-conjugated. For TRIB3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA847220LB01HU TRIB3 Antibody, HRP conjugated ELISA
FITC CSB-PA847220LC01HU TRIB3 Antibody, FITC conjugated
Biotin CSB-PA847220LD01HU TRIB3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity. Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. Can inhibit APOBEC3A editing of nuclear DNA.
Gene References into Functions
  1. A link between TRIB3 and the stereotypical pattern of gray matter loss in Alzheimer's disease. PMID: 29511103
  2. the R141 site of TRIB3 dictates the strength of Akt binding but does not affect other Trbl-dependent developmental processes, suggesting a specificity that could serve as a drug target for metabolic diseases. PMID: 29025897
  3. TRB3 is overexpressed in lesions of patients with psoriasis. PMID: 28790132
  4. tribbles pseudokinase 3 (TRB3) and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity PMID: 28639842
  5. TRIB3, a single-domain protein with impaired kinase catalytic activity, has been described to perform a complex of roles, many of which are likely to be cell type-specific. (Review) PMID: 28393700
  6. High TRB3 expression is associated with basal-like breast cancer. PMID: 27593927
  7. TRIB3 promotes acute promyelocytic leukemia progression through stabilization of the oncoprotein PML-RARalpha and inhibition of p53-mediated senescence. PMID: 28486108
  8. Downregulation of TRIB3 is associated with lung cancer. PMID: 28184934
  9. This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E and what effect semaphorin 3E exerts on carotid atherosclerosis. PMID: 28249916
  10. overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with gastric cancer (GC) . Our findings indicate that TRIB3 is a promising target for antiangiogenic therapy in GC. PMID: 27573078
  11. Our findings suggest that good glucose and blood pressure control exhibited greater benefits on vascular outcomes in patients with TRIB3 (rs2295490) G allele. PMID: 27793583
  12. In this exploratory analysis, IRS1, ENNP1 and TRIB3, known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes. PMID: 26868433
  13. TRIB3 acts as a crucial 'stress adjusting switch' that links homeostasis, metabolic disease and cancer; and is being actively investigated as a disease biomarker and therapeutic target PMID: 26855171
  14. TRB3 is upregulated in macrophages upon treatment with ox-LDL. TRB3 promotes lipid accumulation and suppresses cytokine expression, suggesting inflammation and foam cell formation can be reciprocally regulated. PMID: 26584255
  15. Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis. PMID: 26517922
  16. Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 were involved in the pathogenesis of inflammation. PMID: 26517925
  17. Studies indicate that small molecules can reveal rate-limiting signalling outputs and functions of pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 in cells and intact organisms, serving as guides for the development of new drugs. PMID: 26517930
  18. Studies suggest that the tribbles homolog 3 (Drosophila) protein (TRIB3) Q84R missense polymorphis contributes to atherosclerosis. PMID: 26517932
  19. Studies show a remarkable reduction in tribbles 2 protein (Trib2) expression during oocyte maturation whereas tribbles 1 protein (Trib1) and tribbles 3 protein (Trib3) expression was significantly increased during this process. PMID: 26517934
  20. Studies show that tribbles pseudokinase 3 (TRIB3) plays a crucial role in the anti-cancer activity of cannabinoids and that TRIB3 genetic inactivation enhances cancer generation and progression. PMID: 26517935
  21. TRB3 is an important mediator of palmitate-induced apoptosis in human liver cells, suggesting that it may also be involved in the molecular mechanism underlying PNALD. PMID: 24685558
  22. TRB3 is a novel profibrotic mediator in SSc. TGF-beta induces TRB3, which in turn activates canonical TGF-beta/Smad signaling and stimulates the release of collagen, creating a positive feedback loop that may contribute to aberrant TGF-beta signalling in SSc. PMID: 25603829
  23. Suggest a role of TRIB3 low-frequency variants on coronary artery disease risk among Italian patients with T2D. PMID: 26253791
  24. The results of the present study suggested that TRIB3 was associated with high glucose-induced HUVECs apoptosis, which was attenuated following transfection with TRIB3 siRNA. PMID: 25845379
  25. These results implicate TRIB3 and IGFBP2, both of which are known to be overexpressed in several types of cancers, as pro-survival modulators of cell viability in nutrient-deficient microenvironments. PMID: 26094770
  26. Trib3 interferes with the Parkinson's disease-associated prosurvival protein Parkin to mediate death PMID: 26224857
  27. These observations support the notion that loss of TRIB3 is associated with a more aggressive phenotype in various types of tumors by enhancing the activity of the mTORC2/AKT/FOXO axis. PMID: 25168244
  28. smoking and the TRIB3 G-allele is associated with an increased risk of diabetic nephropathy, which supports the hypothesis that oxidative stress contributes to the development of diabetic nephropathy PMID: 25447894
  29. The correlation between TRB3 and Notch 1 expression revealed that Notch 1 was downregulated by the knockdown of TRB3 in the lung adenocarcinoma cell lines. PMID: 23632994
  30. Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. PMID: 23695665
  31. Results demonstrate that both TRB3 and p21(Cip1) are critical molecules in the homocysteine signaling cascade. PMID: 23349842
  32. We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial. PMID: 23550039
  33. TRIB3 protein is a stable protein which levels are predominantly regulated by translational control of TRIB3 mRNA transcript in breast cancer PMID: 23185332
  34. Data indicate a dominant role for TRB3 and MAPK-ERK/TGFbeta pathways as Notch regulators in breast cancer, establishing TRB3 as a potential therapeutic target. PMID: 23319603
  35. TRB3, through its own cleavage, functions as a molecular switch between the cell survival and apoptotic pathways under stressful conditions PMID: 22912727
  36. Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A PMID: 22977230
  37. molecular mechanisms underlying metabolic and cardiovascular abnormalities [review] PMID: 22577090
  38. TRIB3 is independently associated with poor prognosis of breast cancer patients, possibly through its association with tumor cell hypoxia PMID: 21864376
  39. Studies indicate tribbles 1 and tribbles 3 as regulators of lipid level and disease susceptibility genes in metabolic syndrome and type 2 diabetes. PMID: 22274752
  40. TRIB3 protein is associated with a good prognosis in human breast cancer patients, possibly due to the fact that TRIB3 is involved in hypoxia tolerance. PMID: 21704407
  41. knockdown of endogenous TRB3 expression inhibited the migration and invasion of tumor cells in vitro PMID: 21896644
  42. TRB3 is a critical molecule in the homocysteine-mediated cell-cycle arrest in endothelial cells. PMID: 21935927
  43. TRB3 Q84R polymorphism is associated with obesity and especially glucose metabolism and not associated with polycystic ovary syndrome because of compositional characteristics of phenotype in Chinese PCOS women. PMID: 21492415
  44. HHcy impairs hepatic glycogen synthesis by inducing the expression of TRB3 PMID: 21435438
  45. the GCN2/eIF2alpha/ATF4 pathway is essential for the induction of the TRB3 gene transcription PMID: 21203563
  46. Helicobacter pylori infection is associated with decreased expression of TRIB3 in human gastric epithelial cell lines and tissue samples. PMID: 21220698
  47. The TRIB3 R84 variant is associated with increased carotid IMT also in Caucasians, thus replicating previous data obtained in Asians. In addition, in HUVECs, this variant is associated with unbalanced insulin signalling. PMID: 20693163
  48. Study have found evidence for a role of aberrant hepatic TRIB3 transcript levels in insulin resistance in obese humans and identified potential transcriptional pathways involved in regulation of TRIB3 gene expression in the liver. PMID: 20461355
  49. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. PMID: 20592469
  50. Data confirm that the TRIB3 R84 variant affects glucose homeostasis and suggest this effect is due to an alteration of the interplay between insulin sensitivity and secretion. PMID: 20393693

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Subcellular Location
Nucleus.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily
Tissue Specificity
Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, includ
Database Links

HGNC: 16228

OMIM: 607898

KEGG: hsa:57761

STRING: 9606.ENSP00000217233

UniGene: Hs.516826

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