EIF3J Antibody

Code CSB-PA070117
Size US$100
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  • Western blot analysis of SH-SY5Y 293T 3T3 lysis using eIF3α antibody.

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Product Details

Uniprot No.
Target Names
EIF3J
Alternative Names
eIF 3 alpha antibody; eIF-3-alpha antibody; eIF3 alpha antibody; eIF3 p35 antibody; eIF3j antibody; EIF3J_HUMAN antibody; EIF3S 1 antibody; EIF3S1 antibody; Eukaryotic translation initiation factor 3 subunit 1 antibody; Eukaryotic translation initiation factor 3 subunit J antibody; Eukaryotic translation initiation factor 3; subunit 1 (alpha; 35kD) antibody; Eukaryotic translation initiation factor 3; subunit 1 alpha; 35kD antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human eIF3α.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Gene References into Functions
  1. CK2-phosphorylation of eIF3j at Ser127 promotes the assembly of the eIF3 complex, a crucial step in the activation of the translation initiation machinery. PMID: 25887626
  2. eIF1, eIF1A, eIF3j, and the eIF2-GTP-Met-tRNAi ternary complex stably bind to the 43 S preinitiation complex PMID: 25246524
  3. whether eIF3alpha polymorphism is associated with severe platinum toxicity in patients with non-small cell lung cancer (NSCLC). PMID: 22804784
  4. Beta-Arrestin 2 modulates binding of eIF-3-alpha to selected components of the extracellular signal-regulated kinase pathway. PMID: 22025682
Subcellular Location
Cytoplasm.
Protein Families
EIF-3 subunit J family
Database Links

HGNC: 3270

OMIM: 603910

KEGG: hsa:8669

STRING: 9606.ENSP00000261868

UniGene: Hs.404056

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