Recombinant Human Natural resistance-associated macrophage protein 1 (SLC11A1), partial

1. important roles for c-Src tyrosine kinase in phosphorylation and activation of SLC11A1 in macrophages PMID: 29723216
2. 3'UTR-NRAMP1 gene and VDR-Taq1 gene Polymorphisms are statistically associated with the susceptibility of TB in Andhra Pradesh Population in India. PMID: 28583097
3. Nramp1 is expressed in microglia and neurons in the striatum of human brain and response for degrading alpha-synuclein oligomers in microglia. PMID: 28476637
4. This study identified several important polymorphisms in the ITPKC and SLC11A1 genes in Koreans. PMID: 29214786
5. Studied the role of natural resistance associated macrophage protein 1 (NRAMP1) polymorphisms (D543N, INT4) in pulmonary tuberculosis risk. For D543NA/G polymorphism, no associations were found in all genetic models. For INT4C/G polymorphism, significant increased PTB risk was observed in recessive model. PMID: 28648687
6. This study shows that genetic variations in the candidate gene SLC11A1 do not affect susceptibility to cutaneous leishmaniasis in the sample population from Pakistan. PMID: 28061874
7. in patients with non-muscle-invasive bladder cancer, the NRAMP1 D534N polymorphism could increase the risk of recurrence PMID: 29187939
8. Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta/E2F1 axis-upregulated LSH promoted gliomas. PMID: 28042322
9. Our data suggest that the D543N variant of SLC11A1 gene has a protective effect in the development of rheumatoid arthritis in a Mexican Mestizo population PMID: 28239176
10. The results indicated that genetic variations of D543N (rs17235409) might be associated with susceptibility to cutaneous leishmaniasis infection. PMID: 27681549
11. SLC11A1 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
12. We found a statistical association between polymorphisms in 3'UTR region and exon 8 and CL [chi(2) = 13.26; p < 0.05; OR = 17.00; IC of 95% (2.24-128.99)]. Some patients who needed more than 40 doses of Glucantime(R) to heal injuries presented mutations in exons 3, 8, and 15. Multiple or ear lesions were not associated with NRAMP1 polymorphism. PMID: 27830154
13. distriburtion of polymorphism allelle frequency at the INT4 region associated with oropharyngeal tularemia PMID: 27223255
14. we conclude that presence of G allele of NRAMP1 in both rs2276631 and rs17235409 location may be a protective factor against chronic periodontitis PMID: 27309481
15. our meta-analysis demonstrated that no significant association was identified between genetic susceptibility to UC/CD and polymorphisms of NRAMP1 gene, including (GT)n allele 2, 274 C/T, 1729+55del4 (TGTG) +/del in overall population. PMID: 27019053
16. The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH PMID: 26658322
17. The 274C/T polymorphism in exon 3 and the 469+14G/C polymorphism in intron 4 of the Slc11a1/Nramp1 gene were associated with susceptibility to leprosy, while the allele 2 and 3 of the (GT)n polymorphism in the promoter region were associated with susceptibility and protection to leprosy, respectively. PMID: 26814595
18. investigation of NRAMP1, MBL, MBL, VDR gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis in a Chinese population; study suggests that genotypes of many polymorphic genes are associated with TB PMID: 26261060
19. No significant difference was found for NRAMP1 and hGPX1 gene polymorphisms associated with recurrence time. PMID: 27069153
20. NRAMP1 3'UTR variants were associated with susceptibility to M. tuberculosis infection. PMID: 26578819
21. genetic association studies in population in Mexico: Data suggest an SNP in SLC11A1 (D543N, G/A genotype) is associated with treatment failure (after treatment with combinations of antitubercular agents) in male patients with pulmonary tuberculosis. PMID: 26353180
22. Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases. PMID: 25856512
23. SLC11A1 gene polymorphisms might have a relevant role in the pathology of leishmaniasis, directing towards susceptibility outcome of this disease PMID: 25603101
24. Our data provide insights into the possible role of SLC11A1 variation in visceral leishmaniasis susceptibility. PMID: 25151047
25. Nramp1 expression is up-regulated by cytokines, and its function helps to produce nitric oxide along with other pro-inflammatory responses. [Review] PMID: 26055722
26. Study results have demonstrated, that of all investigated polymorphic variants of genes IL4 (C-590T), IL4RA (150V), TNF (G-308A) and SLC11A1 (D543N) in patients with chronic liver diseases of various etiology PMID: 26281177
27. Highly statistically significant associations were detected between IVS4+44 C/A polymorphism in the DMT1 gene and iron and lead levels (p=0.001 and p=0.036, respectively), but no association was found with cadmium level (p=0.344). PMID: 25483413
28. Polymorphism of the NRAMP1 gene was investigated by PCR amplification followed by RFLP analysis... patients with heterozygosity of intron 4 (GC) and/or maternal infection with helminth parasites showed reduced efficacy of BCG vaccine against tuberculosis PMID: 23408448
29. Polymorphisms in the NRAMP1 gene, VDR gene, HLA-DRB1 gene, and HLA-DQB1 gene are statistically associated with susceptibility to TB in the Chinese Kazakh population. PMID: 24024195
30. Study identifies SLC11A1 as a novel candidate for OM susceptibility, particularly in children with adenoids intact. PMID: 23538334
31. Transcription factor ATF-3 regulates allele variation phenotypes of the human SLC11A1 gene. PMID: 23187734
32. Polymorphisms in SLC11A1 were probably associated with the development of drug-resistant TB in Chinese Han population. PMID: 21457666
33. Our findings reveal an unsuspected role for SLC11A1 in determining Clostridium. difficile pathogenicity PMID: 23690404
34. These results suggest that the Sardinian population might be prone to develop autoimmune disease due to polymorphisms in immunomodulating the SLC11A1 gene. PMID: 23492997
35. In the absence of LSH, the histone variant H2AX is not efficiently phosphorylated in response to DNA damage. PMID: 22946062
36. SLC11A1-expressing lymphocytes are more prone to activation and retention of tyrosine phosphorylation, consistent with a role for inhibition of protein tyrosine phosphatases. PMID: 23509347
37. The bactericidal activity of monocytes in patients with Reactive Arthritis is lower than that in healthy controls. The SLC11A1 274C/T and 823C/T polymorphisms may be associated with the decreased bactericidal activity of the monocytes. PMID: 23244274
38. The T allele of rs2279014 in the 3' untranslated region of SLC11A1 was associated with protection from MAC disease when comparing allele frequencies with an odds ratio of 0.582. PMID: 22387151
39. findings of the present study do not support the hypothesis that Nramp1...might play a role in influencing the growth of bacilli and progression of cavitary tuberculosis rather than susceptibility to M. tuberculosis infection. PMID: 23137204
40. results suggest an association of NRAMP1 3'-UTR and D543N polymorphisms with susceptibility to mycobacterial infection in Tunisian populations in relation to age and sex PMID: 22609013
41. This meta-analysis suggests that polymorphisms in the SLC11A1 gene contribute to TB (both pulmonary TB and extra-pulmonary TB), particularly in Asians PMID: 22326178
42. The results shed light on the role of NRAMP1 in susceptibility to tuberculosis disease and provide a plausible explanation for NRAMP1 and MBL genetic heterogeneity in tuberculosis susceptibility. PMID: 21554230
43. The association between sarcoidosis and four polymorphisms of the SLC11A1 gene, was investigated. PMID: 22160516
44. Report a significant association between SLC11A1 gene variants and pulmonary tuberculosis with respect to susceptibility and subsequent disease progression in East India. PMID: 22008758
45. Homology implies that inverted structural symmetry facilitates Slc11 H(+)-driven Me(2+) import and provides a 3D framework to test structure-activity relationships in macrophages and study functional evolution of MntH/Nramp (Slc11) carriers. PMID: 21948377
46. No associations were observed between visceral leishmaniasis and genetic polymorphisms of SLC11A1 that were either robust to correction for multiple testing or replicated across primary and replication samples. PMID: 21599885
47. conclude that rs3731685 (INT4) in the SLC11A1 gene may be associated with T1D susceptibility in the European ancestry population studied PMID: 21524304
48. The 3'UTR polymorphism of NRAMP1 showed significant correlation with susceptibility to tuberculosis infection. PMID: 21710855
49. association between SLC11A1 polymorphisms and tuberculosis susceptibility analysed by meta-analysis PMID: 21283567
50. recruitment of the SWI/SNF complex initiated Z-DNA formation and subsequently helped to transactivate the SLC11A1 gene. PMID: 21300803

Show More

Hide All

HGNC: 10907

OMIM: 600266

KEGG: hsa:6556

STRING: 9606.ENSP00000233202

UniGene: Hs.591607