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Product Name:

Recombinant human Interleukin-4 protein

Product Type : Recombinant Protein
Code : CSB-RP067374h
Size : 1mg
Uniprot NO. : P05112
Storage : Store at -20℃, for extended storage, conserve at -20℃ or -80℃.
Relevance : Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
Storage Buffer : PBS pH 7.4, 50% glycerol
Purity : 90% ( SDS-PAGE )
Research Area : Immunology
Source : E.coli
Gene Names : IL4,BCGF-1; BCGF1; BSF1; IL-4; MGC79402
Expression Region : 25-153aa
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Product Info : His-tag
Mol. Weight : 19.1kD
Protein Description : Full length
Target details : This protein is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
HGNC : 6014
RGD : 2898
MGI : 96556
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