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Home > Recombinant Protein > Recombinant human Interleukin-6 protein
Product Name:

Recombinant human Interleukin-6 protein

Product Type:
 Recombinant Protein
Application:
 Immunogen，ELISA
Code:
 CSB-RP067574h
Relevance:
 Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
Mol. Weight:
 27 KD
Product Info:
 HIS-tagged
Purity:
 90%
Image:
Storage Buffer:
 PBS buffer
Storage:
 Store at -20℃, for extended storage, conserve at -20℃ or -80℃.
Notes:
 Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Referrences:
 [1] "Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin."
Hirano T., Yasukawa K., Harada H., Taga T., Watanabe Y., Matsuda T., Kashiwamura S., Nakajima K., Koyama K., Iwamatsu A., Tsunasawa S., Sakiyama F., Matsui H., Takahara Y., Taniguchi T., Kishimoto T.
Nature 324:73-76(1986) [PubMed: 3491322] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

[2] "Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene."
Yasukawa K., Hirano T., Watanabe Y., Muratani K., Matsuda T., Nakai S., Kishimoto T.
EMBO J. 6:2939-2945(1987) [PubMed: 3500852] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

[3] "Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved."
May L.T., Helfgott D.C., Sehgal P.B.
Proc. Natl. Acad. Sci. U.S.A. 83:8957-8961(1986) [PubMed: 3538015] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

[4] "Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines."
Zilberstein A., Ruggieri R., Korn J.H., Revel M.
EMBO J. 5:2529-2537(1986) [PubMed: 3023045] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

[5] "Molecular cloning and expression of hybridoma growth factor in Escherichia coli."
Brakenhoff J.P.J., de Groot E.R., Evers R.F., Pannekoek H., Aarden L.A.
J. Immunol. 139:4116-4121(1987) [PubMed: 3320204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

AA sequence:
 VPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKD
GCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDP
TTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
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