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Home > Recombinant Protein > Recombinant human Ubiquitin-like protein ISG15 protein
Product Name:

Recombinant human Ubiquitin-like protein ISG15 protein

Product Type:
 Recombinant Protein
Application:
 Immunogen，ELISA
Code:
 CSB-RP097444h
Relevance:
 Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21

In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy By similarity. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21
Mol. Weight:
 44 KD
Product Info:
 GST tagged
Purity:
 90%
Image:
Storage Buffer:
 PBS buffer, 20mM GSH
Storage:
 Store at -20℃, for extended storage, conserve at -20℃ or -80℃.
Notes:
 Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Referrences:
 [1] "Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence."
Blomstrom D.C., Fahey D., Kutny R., Korant B.D., Knight E. Jr.
J. Biol. Chem. 261:8811-8816(1986) [PubMed: 3087979] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

[2] "Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element."
Reich N., Evans B., Levy D., Fahey D., Knight E. Jr., Darnell J.E. Jr.
Proc. Natl. Acad. Sci. U.S.A. 84:6394-6398(1987) [PubMed: 3476954] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

[3] "A 15-kDa interferon-induced protein is derived by COOH-terminal processing of a 17-kDa precursor."
Knight E. Jr., Fahey D., Cordova B., Hillman M. Jr., Kutny R., Reich N., Blomstrom D.C.
J. Biol. Chem. 263:4520-4522(1988) [PubMed: 3350799] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEOLYTIC PROCESSING.

[4] Erratum
Knight E. Jr., Fahey D., Cordova B., Hillman M. Jr., Kutny R., Reich N., Blomstrom D.C.
J. Biol. Chem. 263:10040-10040(1988)

[5] "Conjugation by ubiquitin-like proteins."
Kamitani T., Fukuda-Kamitani T.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-83.
Tissue: Testis.

AA sequence:
 GWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGLGPGSTV
LLVVDKCDEPLSILVRNNKGRSSTYEVRLTQTVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYG
LKPLSTVFMNLRLRGG
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