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Raw Material for Production of IVD Kit
SLO (native protein)
The streptolysin prime O (SLO), is one of the metabolites of group A streptococ. It can dissolve human red blood cells and has strong antigenicity. If body infects group A streptococcal from pharyngitis, tonsillitis, scarlet fever, erysipelas, pyoderma or rheumatic fever, the body can produce Anti-Streptolysin O(ASO). ASO determination is of great value for the diagnosis of group A streptococcal infection, The existence and content can reflect the severity of the infection.
Binding with the latex particles, the SLO encounter with the ASO of the samples in the liquid phase, forming a antigen-antibody complex. The turbidity will be a certain percentage in the linear range. Compared with the calibrator, we can calculate the ASO in the sample.
More than a dozen of companies supply SLO protein in the international market. Most of them cannot cater to the development and production requirements of ASO diagnostic reagents based on the latex method, because of some existing problem about stability, production, immune activity. However, a few available raw materials are extremely costly! Developed independently, the SLO protein from CUSABIO has been used for the production in the latex reagents successfully, which is turn out to be excellent in absorbance, specificity and stability. With complete advanced equipment and rich experience, our protein is manufactured in a stable process and at a low production costs. Now, the protein yield up to 1g every month(for 100L reagents). We can enlarge the production easily, and guarantee the supply of raw materials in large-scale and long-term.
NGAL protein & antibody
Emerging biomarkers for acute kidney injury.
Neutrophil gelatinase transfer protein (NGAL) is an early renal injury and sensitive biomarkers. NGAL level has significant increase within two hours of kidney injury; the Danish Bioporto first developed out of NGAL ELISA kit in 2005 and got the CE certification in 2006. It can be used for clinical diagnosis and monitoring of acute renal injury. At present, only one company Abbott is a listing approval in May 2011.
At the end of 2011, we successfully develop the NGAL protein and corresponding polyclonal antibody. Compared with the products of Biopotro, our products are detected comprehensively. Based on the resulting data, our products are almost at the same level of Biopotro, no matter in specificity, sensitivity, stability, absorbance or clinical sample. In addition, our NGAL protein and antibody has been validated by many terminal customers, finding it available to use for developing the NGAL clinical diagnostic kit, which is based on elisa and latex enhanced immunoturbidimetric assay(LETID).
RBP4 protein & antibody
Retinol binding protein 4(RBP4) is a transporter protein of vitamin in the blood which is synthesized by the liver, widely distributed in the blood, cerebrospinal fluid, urine and other body fluids. Determination of retinol-binding protein in early detection can help find out renal tubular dysfunction, and sensitively reflect the extent of damage of the renal proximal tubule damage. It can be also used as early liver function and guardianship treatment indicators With the highly quality in heat-damage, long-term stability, linearity and 99 percentage in purity, our RBP4 protein is a good immunogen for production of antibodies. The titer and specificity of corresponding rabbit & goat polyclonal antibody have already been validated. It is of value for the further more requirement for diagnostic reagents.
CysC protein & antibody
Cystine protease inhibitor C (CysC) is a relatively close to the ideal reflect endogenous marker of glomerular filtration rate. Studies show that the substance can't be infected by physical, gender, age, inflammation and other factors and the body content is constant. Compared with serum BUN, Cr has higher sensitivity and specificity. There is a very important value for the evaluation of glomerular filtration rate. It can sensitively prompt the early renal damage and is an ideal indicator for new findings of diagnose kidney disease. The current CysC diagnostic reagent market is very hot, and the products such as quality control, calibrators and the antibody are almost completely imported. Out independently developed CysC protein already tested by many domestic and foreign companies' reagent. Linearity, stability and other indicators are in line with the standard that can be fully used for quality control and calibration products. The specificity, responsiveness and linear stability of the antibody-corresponding latex reagent all reach the imported similar raw materials' level, and we have used less antibody, so the cost is much lower.
Other products include cTnI, B2M, IFN-, FABP3, galectin3, WFDC2, HA, MB