HMGB1

Code CSB-CL010553PI
Size 10 μg plasmid + 200μl Glycerol
Uniprot No. P12682
Relevance Sus scrofa high mobility group box 1 (HMGB1), mRNA.
Species Sus scrofa (Pig)
Vector pUC
Sequence at gggcaaagga gatcctaaga agccgagagg caaaatgtca tcatatgcattctttgtgca aacttgccgg gaggagcata agaagaagca cccagatgct tcagtcaacttctcagagtt ttctaagaag tgctcagaaa ggtggaagac catgtctgct aaagagaaaggaaaatttga agacatggca aaggcggaca aggcccgtta tgaaagagaa atgaaaacttacatacctcc taaaggggag acaaaaaaga agttcaagga tcccaatgca cccaagaggcctccttcggc ctttttcttg ttttgttctg agtatcgtcc aaaaatcaaa ggagagcatcctggcctatc cattggtgat gttgcaaaga aactgggaga gatgtggaat aacaccgctgcagatgacaa gcacccttat gaaaagaagg ctgctaagct gaaggagaag tacgaaaaggatattgctgc ataccgagct aaagggaagc ctgatgcagc aaaaaaggga gtcgtcaaggctgagaaaag caagaaaaag aaggaagagg aggaagatga ggaagatgaa gaggatgaggaggaggagga ggacgaagag gatgaggagg aagaagaaga tgatgatgat gaataa
Gene Names HMGB1
Accession NO. NM_001004034.1
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Function Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins (By similarity).
Subcellular Location Nucleus, Chromosome, Cytoplasm, Secreted, Cell membrane, Peripheral membrane protein, Extracellular side, Endosome, Endoplasmic reticulum-Golgi intermediate compartment
Protein Families HMGB family
Database Links

KEGG: ssc:445521

STRING: 9823.ENSSSCP00000009955

UniGene: Ssc.22696

Pathway Autophagy
Necroptosis
DNA repair pathway

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