Bovine Complement factor B(CFB) ELISA kit

Code CSB-EL005268BO
See More Details 24T ELISA kits trial application
Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. P81187
Lead Time 5-7 working days
Abbreviation CFB
Protein Biological Process 1 Complement
Target Name complement factor B
Alias DADB-122G4.5, AHUS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2, B-factor, properdin|C3 proaccelerator|C3 proactivator|C3/C5 convertase|OTTHUMP00000174690|glycine-rich beta-glycoprotein
Species Bos taurus (Bovine)
Protein Biological Process 3 Complement alternate pathway
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Target Details This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5 end of the gene for complement component 2.
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Function Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments
Subcellular Location Secreted
Protein Families Peptidase S1 family
Database Links

KEGG: bta:514076

STRING: 9913.ENSBTAP00000009800

UniGene: Bt.13542

Pathway Complement and coagulation cascades

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