Bovine Sclerostin(SOST) ELISA kit

Unavailable
Code CSB-EL022415BO
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. Q9BG79
Lead Time 5-7 working days
Abbreviation SOST
Protein Biological Process 1 Signaling Pathway
Target Name sclerosteosis
Alias VBCH, sclerostin
Species Bos taurus (Bovine)
Protein Biological Process 3 Wnt signaling pathway
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Target Details Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
HGNC 13771
RGD 69358
MGI 1921749
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Function Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Sclerostin family
Database Links

STRING: 9913.ENSBTAP00000017458

UniGene: Bt.13086

Pathway Wnt signaling pathway

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