Chicken Cadherin-1(CDH1) ELISA kit

Code CSB-EL005034CH
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. P08641
Lead Time 5-7 working days
Abbreviation CDH1
Protein Biological Process 1 Cell Adhesion
Target Name cadherin 1, type 1, E-cadherin (epithelial)
Alias Arc-1, CD324, CDHE, ECAD, LCAM, UVO, E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin 1, type 1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|uvomorulin
Species Gallus gallus (Chicken)
Protein Biological Process 3 Cell adhesion
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cancer
Target Details This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
HGNC 1748
RGD 69279
MGI 88354
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Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha-E/beta-7.
Subcellular Location Cell membrane, Single-pass type I membrane protein
Tissue Specificity Non-neural epithelial tissues.
Database Links

KEGG: gga:415860

UniGene: Gga.2982

Pathway Hippo signaling pathway
Adherens junction
Apelin signaling pathway
Rap1 signaling pathway

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