Dog Apolipoprotein E(APOE) ELISA kit

Code CSB-EL001936DO
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. P18649
Lead Time 5-7 working days
Abbreviation APOE
Protein Biological Process 1 Apolipoprotein
Target Name apolipoprotein E
Alias AD2, LDLCQ5, LPG, MGC1571, apolipoprotein E3
Species Canis lupus familiaris (Dog) (Canis familiaris)
Protein Biological Process 3 Lipid transport
Sample Types serum, plasma, tissue homogenates
Detection Range 31.25 ng/mL-2000 ng/mL
Sensitivity 7.81 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cardiovascular
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Assay Principle quantitative
Measurement Sandwich
Target Details Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
HGNC 613
RGD 2138
MGI 88057
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Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Subcellular Location Secreted
Protein Families Apolipoprotein A1/A4/E family
Tissue Specificity Present in multiple tissues including liver, jejunum, urinary bladder, ileum, colon, brain, kidney, spleen, pancreas and testis. Secreted in plasma.
Database Links

STRING: 9615.ENSCAFP00000006888

UniGene: Cfa.16211

Pathway Cholesterol metabolism

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