Human Annexin Ⅳ(ANX-Ⅳ) ELISA Kit

Code CSB-E12158h
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name annexin A4
Alternative Names 35 beta calcimedin ELISA Kit; 35-beta calcimedin ELISA Kit; AIV ELISA Kit; Annexin 4 ELISA Kit; Annexin A4 ELISA Kit; Annexin IV (placental anticoagulant protein II) ELISA Kit; Annexin IV ELISA Kit; Annexin IV placental anticoagulant protein II ELISA Kit; Annexin-4 ELISA Kit; AnnexinA4 ELISA Kit; AnnexinIV ELISA Kit; ANX 4 ELISA Kit; ANX A4 ELISA Kit; ANX4 ELISA Kit; ANXA 4 ELISA Kit; ANXA4 ELISA Kit; ANXA4 protein ELISA Kit; ANXA4_HUMAN ELISA Kit; Carbohydrate binding protein P33/P41 ELISA Kit; Carbohydrate-binding protein p33/p41 ELISA Kit; Chromobindin 4 ELISA Kit; Chromobindin-4 ELISA Kit; Chromobindin4 ELISA Kit; DKFZp686H02120 ELISA Kit; Endonexin I ELISA Kit; EndonexinI ELISA Kit; Lipocortin IV ELISA Kit; LipocortinIV ELISA Kit; MGC75105 ELISA Kit; OTTHUMP00000160052 ELISA Kit; OTTHUMP00000202207 ELISA Kit; P32.5 ELISA Kit; P33/41 ELISA Kit; PAP II ELISA Kit; PAP-II ELISA Kit; PAPII ELISA Kit; PIG 28 ELISA Kit; PIG28 ELISA Kit; Placental anticoagulant protein II ELISA Kit; PP4 X ELISA Kit; PP4-X ELISA Kit; PP4X ELISA Kit; Proliferation inducing gene 28 ELISA Kit; Proliferation inducing protein 28 ELISA Kit; Protein II ELISA Kit; Xanx-4 ELISA Kit; ZAP 36 ELISA Kit; ZAP36 ELISA Kit
Abbreviation ANXA4
Uniprot No. P09525
Species Homo sapiens (Human)
Sample Types serum, plasma, tissue homogenates
Detection Range 78 pg/mL-5000 pg/mL
Sensitivity 19.5 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Assay Principle quantitative
Measurement Sandwich
and FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Target Data

Function Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Gene References into Functions
  1. ANXA4 expression was increased at both the mRNA and protein level in the drugresistant ovarian cancer cells, and ANXA4 contained a Lewis(y) structure. ANXA4 overexpression can abnormally activate signaling pathways and regulate the expression of a numbers of factors, forming a positive feedback loop to induce the chemoresistance of ovarian cancer cells. PMID: 30066907
  2. Annexin A4 binds to artificial membranes and generates curvature force initiated from free edges, whereas annexin A6 induces constriction force. PMID: 29158488
  3. Taken together, these data indicate that up-regulation of ANXA4 leads to activation of the NF-kappaB pathway and its target genes in a feedback regulatory mechanism via the p65 subunit, resulting in tumor growth in GBC. PMID: 27491820
  4. Upregulation and nuclear translocation of ANXA4 have been observed in the progression of colorectal cancer and ovarian serous carcinoma. Knockdown of ANXA4 attenuated migration in ovarian cancer and breast cancer cells. In contrast, knockdown of ANXA4 increased susceptibility to platinum in ovarian cancer and malignant mesothelioma cells. Review. PMID: 27100483
  5. Study identifies ANXA4 and FLNA as up-regulated in buccal squamous cell carcinoma arising from oral submucous fibrosis. PMID: 27485544
  6. High ANXA4 expression is associated with metastasis of hepatocellular carcinoma. PMID: 26779633
  7. annexin A4 can be regarded as an important molecular marker in triple-negative breast cancer prognosis. PMID: 27650619
  8. role of annexin A4 in cancer PMID: 26048190
  9. Data shows that CYTB and ANXA4 overexpression may be involved in carcinogenesis and histopathological differentiation of ovarian clear cell carcinoma and suggest they may serve as a potential diagnostic biomarkers. PMID: 25633807
  10. These findings indicate that the calcium-binding site in the ANXA4 repeat induces chemoresistance to the platinum-based drug by elevating the intracellular chloride concentration. PMID: 25277200
  11. Fhit delocalizes annexin A4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. PMID: 24223161
  12. enhanced expression of Anx A4 confers platinum resistance by promoting efflux of platinum drugs via ATP7A. PMID: 24150977
  13. This study showed that overexpression and nuclear localization of annexin A4 are related to chemoresistance and poor survival in patients with serous papillary ovarian carcinomas. PMID: 23290009
  14. suggest that ANXA4 triggers a signaling cascade, leading to increased epithelial cell proliferation, ultimately promoting carcinogenesis PMID: 22970268
  15. Lower expression of annexin A4 during window of implantation in infertile patients with endometriosis might be associated with the decrease of endometrial receptivity. PMID: 22883517
  16. Eight ANXA4 polymorphisms are significantly associated with the risk of aspirin-exacerbated respiratory disease. PMID: 22847161
  17. that H3K4 tri- and dimethylation play an important role and that JARID1A is the histone-demethylating enzyme responsible for removal of this mark PMID: 21348943
  18. In an Alzheimer model, transgenic mice overexpressing mutant human amyloid precursor protein (APP) show a significant increase of annexin A5 in the brain cortex but not in other organs, including liver, kidney, lung, and intestine. PMID: 20648654
  19. Annexin A4 differentially modulates the NF-kappaB signaling pathway, depending on its interactions with p50 and the intracellular Ca(2+) ion level. PMID: 20237821
  20. The overexpression of Annexin IV may be an ovarian CCC-specific molecular marker. PMID: 19955935
  21. annexin IV plays an important role in the morphological diversification and dissemination of the clear cell renal cell carcinoma PMID: 15145526
  22. This work provides mechanistic insight into how annexin A4 may regulate plasma membrane protein function. PMID: 16687573
  23. ANXA4 transcription and translation are regulated by progesterone. ANXA4 may be important in regulating ion and water transport across the endometrial epithelium. PMID: 16954445
  24. There were no significant differences in plasma annexin IV levels between women with and without antiphospholipid antibodies PMID: 17363042
  25. Enhanced expression of Annexin A4 is associated with clear cell carcinoma of the ovary PMID: 19598262

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Protein Families Annexin family
Database Links

HGNC: 542

OMIM: 106491

KEGG: hsa:307

STRING: 9606.ENSP00000377833

UniGene: Hs.422986

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