Human Annexin Ⅶ(ANX-Ⅶ) ELISA Kit

Instructions
Code CSB-E12160h
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name annexin A7
Alternative Names Annexin A7 ELISA Kit; Annexin VII ELISA Kit; Annexin-7 ELISA Kit; ANX7 ELISA Kit; ANXA7 ELISA Kit; ANXA7_HUMAN ELISA Kit; SNX ELISA Kit; Synexin ELISA Kit
Abbreviation ANXA7
Uniprot No. P20073
Species Homo sapiens (Human)
Sample Types serum, plasma, tissue homogenates, cell lysates
Detection Range 1.25 ng/mL-80 ng/mL
Sensitivity 0.31 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Target Data

Function Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Gene References into Functions
  1. Overexpression of ANXA7 enhances eucalyptol cytotoxicity in prostate cancer cell lines PMID: 29970503
  2. Up-regulation of ANXA7-GTPase tumor suppressor reverses tumorigenesis. (Review) PMID: 27807828
  3. Study demonstrates that annexin A7 protein has an important role in gastric cancer. Silencing the expression of ANXA7 in vitro and in vivo induces the apoptosis of BGC823 gastric cancer cells and, importantly, inhibits the growth of tumor xenografts in mice. PMID: 28176245
  4. data reveal that high UBE3C expression contributes to glioma progression by ubiquitination and degradation of ANXA7, and thus presents a novel and promising target for glioma therapy. PMID: 26067607
  5. High annexin A7 expression is associated with poor differentiation in gastric cancer patients, and it may be a predictor for lymphatic metastasis. PMID: 25400735
  6. miRNA-155 promoted the proliferation of prostate cancer cells by regulating ANX7 expression levels. PMID: 25339368
  7. The role of distinct SGK1/FOXO3A-associated regulation in p53 versus ANXA7 responses were elucidated and proposed that aberrant SGK1 could affect reciprocal SGK1-FOXO3A-Akt regulation. PMID: 24864229
  8. Alternative ANXA7 splicing was present in precursor cells, suggesting that glioblastoma cells inherit the trait from a potential tumor-initiating ancestor and that these cells exploit this the through accumulation of mutations that enhance EGFR signaling. PMID: 24865424
  9. Both annexin A7 and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy. PMID: 24007983
  10. Annexin A7 expression was able to inhibit HCC lymph node metastasis, whereas knockdown of Annexin A7 expression significantly induced HCC metastasis to local lymph nodes. PMID: 24188284
  11. We have found ANXA7 to be functioning like a tumour promoter in HepG2 human hepatocellular carcinoma cells PMID: 23582794
  12. The present observations demonstrate that enhanced eryptosis of annexin7 deficient cells is paralleled by increased adhesion of erythrocytes to the vascular wall, an effect, which may impact on microcirculation during ischemia. PMID: 23437197
  13. by identifying ABO as an unprecedented modulator of ANXA7 as well as GCA and LC3 as interacting proteins of ANXA7, we demonstrated the possible mechanisms how ANXA7 regulates autophagy for the first time. PMID: 23651924
  14. The study data have demonstrated the pathogenic roles and therapeutic significance of Anx7 in RA for the first time. PMID: 21586441
  15. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function. PMID: 21531385
  16. Annexin A7 may be involved in the pathophysiology of refractory epilepsy and may play a role in developing and maintaining the epilepsy PMID: 21432772
  17. The study indicates that stomatin, sorcin, and synexin are echinophilic membrane components that mainly locate outside GM1 rafts in the human erythrocyte membrane. PMID: 20858460
  18. A7 and A11 have sequence repeats that form novel structures, called YP pro-beta helices, that are characterized by an ability to interact with one another PMID: 20093729
  19. a multi-hnRNP complex can be responsible for aberrant ANXA7 transcription and splicing, thereby affecting ANXA7 expression pattern and tumor suppressor function in prostate cancer. PMID: 20190808
  20. synexin mediates galectin-3 translocation to the perinuclear mitochondrial membranes, where it regulates mitochondrial integrity critical for apoptosis regulation. PMID: 11839755
  21. the calcium-dependent membrane fusion activity of annexin 7 in vitro is further potentiated by the combined addition of guanine nucleotide and protein kinase C PMID: 11994295
  22. The penta-EF-hand domain of ALG-2 interacts with the amino-terminal domain of annexin VII in a Ca2+-dependent manner. PMID: 12445460
  23. Annexin VII was present in reticulocytes but was then lost as the cells matured. A different pattern was found in band 3-deficient samples: annexin VII was in fact present in both mature and immature red cell membranes. PMID: 17112522
  24. Decreased ANXA7 expression was mostly associated with high invasive potential in multiple tumors. The lymph node metastases from different sites (including prostate and breast) had decreased ANXA7 expression. PMID: 17708571
  25. correlation between ANXA7 expression and cell differentiation of gastric cancer was observed PMID: 18449914
  26. Haploinsufficiency of the tumor suppressor ANXA7 due to monosomy of chromosome 10 provides a clinically relevant mechanism to augment EGFR signaling in glioblastomas beyond that resulting from amplification of the EGFR gene. PMID: 19602687

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Protein Families Annexin family
Tissue Specificity Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta.
Database Links

HGNC: 545

OMIM: 186360

KEGG: hsa:310

STRING: 9606.ENSP00000362010

UniGene: Hs.631827

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