Human Fibroblast growth factor 16(FGF16) ELISA kit

Instructions
Code CSB-EL008621HU
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name fibroblast growth factor 16
Alternative Names FGF 16 ELISA Kit; FGF-16 ELISA Kit; Fgf16 ELISA Kit; FGF16_HUMAN ELISA Kit; Fibroblast growth factor 16 ELISA Kit
Abbreviation FGF16
Uniprot No. O43320
Species Homo sapiens (Human)
Sample Types serum, plasma, tissue homogenates
Detection Range 500 pg/mL-7.81 pg/mL
Sensitivity 1.95 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Data

Function Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.
Gene References into Functions
  1. Experiments demonstrated FGF16 could promote proliferation of NCL-H460 cells by activating Akt, Erk1/2, and p38 MAPK signaling, whereas JNK had no significant effect. PMID: 28409700
  2. Identification of an FGF16 mutation in metacarpal 4-5 fusion. PMID: 24878828
  3. impaired FGF16 function may also be responsible for connective tissue symptoms in MF4 patients. PMID: 24706454
  4. Fgf-16 gene is a target for NF-kappaB activation in the postnatal heart. PMID: 20097674
  5. HUVEC clearly demonstrated chemotaxis towards FGF16. FGF16 enhanced cell migration in response to mechanical damage & failed to induce endothelial cell proliferation or sprouting in a three-dimensional in vitro angiogenesis assay. PMID: 16756958

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Involvement in disease Metacarpal 4-5 fusion (MF4)
Subcellular Location Secreted
Protein Families Heparin-binding growth factors family
Database Links

HGNC: 3672

OMIM: 300827

KEGG: hsa:8823

STRING: 9606.ENSP00000399324

UniGene: Hs.666364

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