Human Galectin-4(LGALS4) ELISA kit

Instructions
Code CSB-EL012889HU
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name lectin, galactoside-binding, soluble, 4
Alternative Names Antigen NY CO 27 ELISA Kit; Antigen NY-CO-27 ELISA Kit; Antigen NYCO27 ELISA Kit; GAL 4 ELISA Kit; Gal-4 ELISA Kit; GAL4 ELISA Kit; Galectin 4 ELISA Kit; Galectin-4 ELISA Kit; Galectin4 ELISA Kit; Homo sapiens galectin4 mRNA complete cds ELISA Kit; L 36 lactose binding protein ELISA Kit; L-36 lactose-binding protein ELISA Kit; L36 lactose binding protein ELISA Kit; L36LBP ELISA Kit; Lactose binding lectin 4 ELISA Kit; Lactose-binding lectin 4 ELISA Kit; Lectin galactoside binding soluble 4 ELISA Kit; LEG4_HUMAN ELISA Kit; LGALS4 ELISA Kit
Abbreviation LGALS4
Uniprot No. P56470
Species Homo sapiens (Human)
Sample Types serum, plasma, tissue homogenates
Detection Range 0.156 ng/mL-10 ng/mL
Sensitivity 0.039 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Others
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Data

Function Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
Gene References into Functions
  1. Data show that galectin-4 expressing tumor cells interact directly with red blood cells (RBCs). PMID: 28293788
  2. Haplotype formed from two promoter SNPs rs116896264 and rs73933062 is associated with galectin-4 overexpression in colorectal cancer. PMID: 26681582
  3. LGALS4 may function as a tumor suppressor gene in UC progression. Findings provide evidence that methylation-mediated LGALS4 gene repression may be involved in urothelial tumor progression. PMID: 28423602
  4. Together, the data demonstrated that surface-bound galectin-4 is a dual function protein-down-regulating cell proliferation and chemokine secretion in galectin-4-expressing colorectal cancer cells on one hand and inducing apoptosis in galectin-4-negative colorectal cancer cells on the other hand. PMID: 28345468
  5. The carbohydrate-binding site is composed of residues His236, Asn238, Arg240, Asn249, Trp256, Glu259 and Lys261 at the strands S4, S5 and S6. PMID: 26432949
  6. The data suggests that arm-Gal4 has detrimental effects on Drosophila development and lifespan that are directly dependent upon parental inheritance PMID: 26505429
  7. The co-expression of galectin-4 and CNT3 proteins is not impaired in inflamed colon from patients with Crohn's disease, thereby anticipating the integrity of this system for drug targeting. PMID: 26481311
  8. Structural characterization of human galectin 4 C-terminal domain in terms its ligands binding specificity has been reported. PMID: 26077389
  9. role in basolateral to apical epithelial transcytosis PMID: 25179596
  10. The results show galectin-4 expression closely associates with hepatocellular carcinoma (HCC) progression and might have potential use as a prognostic biomarker for HCC patients. PMID: 25230111
  11. Galectin-4 plays an important role in metastatic process of lung adenocarcinoma. PMID: 24339976
  12. Data indicate that galectin-4 elicits tumor promotion in vitro and in vivo through activation of IL-6/NF-kappaB/STAT3 signaling. PMID: 23378274
  13. Loss of Galectin-4 is associated with colorectal cancer. PMID: 21064109
  14. crystals of galectin-4 belonged to space group P6(1)22, with unit-cell parameters a = b = 71.25, c = 108.66 A. PMID: 20445255
  15. microarray study in sinonasal adenocarcinoma we identified proteins, LGALS4 that is significantly differentially expressed in tumors compared to normal tissue PMID: 19903339
  16. results suggest that galectin-4 has a unique carbohydrate binding specificity and interacts with O-linked sulfoglycans PMID: 11971864
  17. SB1a and CEA in the patches on the cell surface of human colon adenocarcinoma cells could be biologically important ligands for galectin-4 PMID: 15546874
  18. Together, our data propose that interaction between galectin-4 and sulfatides plays a functional role in the clustering of lipid rafts for apical delivery. PMID: 15883199
  19. Galectin 4 induces surface phosphatidylserine exposure in a carbohydrate-dependent fashion in activated, but not resting, human neutrophils and in several leukocyte cell lines. PMID: 16940423
  20. not only sulfated glycosphingolipids but also cholesterol 3-sulfate are endogenous ligands for galectin-4 in vivo PMID: 17545668
  21. chemical analysis of talose-selectivity of galectin-4 and galectin-8 PMID: 18539029
  22. Data show that the pattern of N-glycosylation of glycoproteins serves as a recognition signal for endocytosed galectin-4, which drives the raft-dependent apical pathway of glycoproteins in enterocyte-like HT-29 cells. PMID: 19192249

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Database Links

HGNC: 6565

OMIM: 602518

KEGG: hsa:3960

STRING: 9606.ENSP00000302100

UniGene: Hs.5302

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