Human Haptoglobin Related Protein (HPR)ELISA Kit

Instructions
Code CSB-EL010705HU
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name Haptoglobin Related Protein (HPR)
Alternative Names A-259H10.2 ELISA Kit; Haptoglobin related locus ELISA Kit; haptoglobin related protein ELISA Kit; Haptoglobin-related protein ELISA Kit; HP ELISA Kit; hpr ELISA Kit; HPTR_HUMAN ELISA Kit
Abbreviation HPR
Uniprot No. P00739
Species Homo sapiens (Human)
Sample Types serum, plasma,tissue homogenates
Detection Range 1.87 ng/mL-120 ng/mL
Sensitivity 0.46 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cardiovascular
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Target Data

Function Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
Gene References into Functions
  1. the haptoglobin (HP) rs8062041 appeared to be protective against African Trypanosomiasis; HPR is adjacent to HP and is a component of the Trypanolytic factor; the HP and HPR locus is duplicated in some people; the rs8062041 variant may be associated with this duplication and it is possible that increased production of HPR is the cause of protection associated with rs806204 PMID: 29077717
  2. Data indicate that haptoglobin-related protein (Hpr) is presented at the surface of hepG2 cells. PMID: 25037218
  3. show that trypanosome lytic factor-1 resistance in Trypanosoma brucei brucei is caused by reduced expression of the Hp/Hb receptor gene. PMID: 20805508
  4. No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein PMID: 11814582
  5. recombinant Hpr binds hemoglobin as efficiently as haptoglobin PMID: 16778136
  6. apoL-I is responsible for the trypanolytic activity of normal human serum, whereas Hpr allows fast uptake of the carrier HDL particles in trypanolysis PMID: 17360487
  7. Infection by Trypanosoma brucei brucei causes hemolysis that triggers activation of trypanosome lytic factor by formation of haptoglobin-related protein-hemoglobin complexes, enhancing binding, trypanolytic activity, and clearance of parasites. PMID: 17845074
  8. at low pH. Trypanosome lytic factor, apoL-1, and apoA-1 exhibit specificity for anionic membranes, whereas Hpr permeabilizes both anionic and zwitterionic membranes. PMID: 19324878

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Subcellular Location Secreted
Protein Families Peptidase S1 family
Tissue Specificity In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell
Database Links

HGNC: 5156

OMIM: 140210

KEGG: hsa:3250

STRING: 9606.ENSP00000441828

UniGene: Hs.655361

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