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Human Interleukin-11 receptor subunit alpha(IL11RA) ELISA kit

Code CSB-EL011584HU
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name interleukin 11 receptor, alpha
Alternative Names CRSDA ELISA Kit; hCG_2011440 ELISA Kit; I11RA_HUMAN ELISA Kit; IL-11 receptor subunit alpha ELISA Kit; IL-11R subunit alpha ELISA Kit; IL-11R-alpha ELISA Kit; IL-11RA ELISA Kit; IL11RA ELISA Kit; Interleukin 11 receptor alpha ELISA Kit; Interleukin 11 receptor alpha chain ELISA Kit; Interleukin-11 receptor subunit alpha ELISA Kit; MGC2146 ELISA Kit
Abbreviation IL11RA
Uniprot No. Q14626
Species Homo sapiens (Human)
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Troubleshooting
and FAQs		 ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Data

Function Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
Gene References into Functions
  1. The results presented here reveal an additional function in classic IL-11 signaling, highlighting the importance of the IL-11R stalk in IL-11 signaling PMID: 29523682
  2. The D2 domain of the IL-11R contains two N-linked glycans, which are dispensable for its biological activity, but differentially control maturation and intracellular trafficking of the receptor. PMID: 29533934
  3. High IL11RA expression is associated with endometrioid tumours. PMID: 28186993
  4. Report IL11RA and MELK amplification in gastric cancer cell lines and primary gastric adenocarcinomas. PMID: 27920471
  5. These results indicate that IL-11Ralpha is a potential target for the development of molecular targeted therapy and noninvasive tumor imaging in human osteosarcoma. PMID: 25524575
  6. IL11RA promoter polymorphism--rs1061758--may be associated with the risk of papillary thyroid cancer in the Korean population. PMID: 21982075
  7. data suggest that IL-11Ralpha-CAR T cells may represent a new therapy for patients with osteosarcoma pulmonary metastases PMID: 22075555
  8. IL11 as well as IL11RA are likely to play a role in the progression of endometrial carcinoma. PMID: 20553623
  9. IL-11Ralpha was expressed in both epithelial and stromal cells, with epithelial staining being more intense PMID: 12200462
  10. the interleukin-11 receptor alpha-chain has evidence of antiapoptotic effects in human colonic epithelial cells PMID: 14701802
  11. IL-11Ralpha is a candidate target for translational clinical trials against advanced and metastatic prostate cancer. PMID: 14744752
  12. interleukin-11 receptor is expressed in CD38-positive cells from patients with multiple myeloma PMID: 15512823
  13. High expression of interleukin-11 receptor alpha is associated with Hodgkin's lymphoma PMID: 16291580
  14. High interleukin 11 receptor is associated with breast cancer PMID: 16614887

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Involvement in disease Craniosynostosis and dental anomalies (CRSDA)
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Type I cytokine receptor family, Type 3 subfamily
Tissue Specificity Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malig
Database Links

HGNC: 5967

OMIM: 600939

KEGG: hsa:3590

STRING: 9606.ENSP00000326500

UniGene: Hs.591088
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