Human Interleukin-12 receptor subunit beta-1 (IL12RB1/IL12R/IL12RB) ELISA kit

Code CSB-E17380h
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. P42701
Lead Time 3-5 working days
Abbreviation IL12RB1
Target Name interleukin 12 receptor, beta 1
Alias CD212, IL-12R-BETA1, IL12RB, MGC34454, IL-12 receptor beta component|interleukin-12 receptor beta-1 chain
Species Homo sapiens (Human)
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Target Details This protein is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
HGNC 5971
MGI 104579
References
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Function Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Involvement in disease Immunodeficiency 30 (IMD30)
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Type I cytokine receptor family, Type 2 subfamily
Database Links

HGNC: 5971

OMIM: 601604

KEGG: hsa:3594

STRING: 9606.ENSP00000403103

UniGene: Hs.567294

Pathway Jak-STAT signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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