Human Interleukin-12 subunit alpha(IL12A) ELISA kit

Code CSB-EL011586HU
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. P29459
Lead Time 7-14 working days
Abbreviation IL12A
Target Name interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Alias CLMF, IL-12A, NFSK, NKSF1, P35, IL-12, subunit p35|NF cell stimulatory factor chain 1|cytotoxic lymphocyte maturation factor 1, p35|interleukin 12, p35|interleukin 12A|interleukin-12 alpha chain|nat
Species Homo sapiens (Human)
Sample Types serum, plasma, cell culture supernates
Detection Range 15.6 pg/mL-1000 pg/mL
Sensitivity 3.9 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Assay Principle quantitative
Measurement Sandwich
Target Details This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
HGNC 5969
RGD 620562
MGI 96539
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Function Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Subcellular Location Secreted
Protein Families IL-6 superfamily
Database Links

HGNC: 5969

OMIM: 161560

KEGG: hsa:3592

STRING: 9606.ENSP00000303231

UniGene: Hs.673

Pathway Jak-STAT signaling pathway
Th1 and Th2 cell differentiation
Toll-like receptor signaling pathway

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