Human Leucine-rich repeat LGI family member 4(LGI4) ELISA kit

Instructions
Code CSB-EL012901HU
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name leucine-rich repeat LGI family, member 4
Alternative Names Leucine rich glioma inactivated gene 4 ELISA Kit; Leucine rich glioma inactivated protein 4 ELISA Kit; Leucine rich repeat LGI family member 4 ELISA Kit; Leucine-rich glioma-inactivated protein 4 ELISA Kit; Leucine-rich repeat LGI family member 4 ELISA Kit; LGI1 like protein 3 ELISA Kit; LGI1-like protein 3 ELISA Kit; LGI4 ELISA Kit; Lgi4 protein ELISA Kit; LGI4_HUMAN ELISA Kit; Lgil3 ELISA Kit
Abbreviation LGI4
Uniprot No. Q8N135
Species Homo sapiens (Human)
Sample Types serum, plasma, tissue homogenates
Detection Range 0.39 ng/mL-25 ng/mL
Sensitivity 0.09 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Neuroscience
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Data

Function Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity).
Gene References into Functions
  1. in four unrelated multiplex families presenting with severe arthrogryposis multiplex congenital, identified biallelic loss-of-function mutations in LGI4; functional tests showed these germline mutations caused aberrant splicing of the endogenous LGI4 transcript and in a cell-based assay impaired the secretion of truncated LGI4 protein PMID: 28318499
  2. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. PMID: 24662834
  3. The positive genotypic association between benign familial infantile convulsions (BFIC)and c.1722G/A polymorphism suggests that LGI4 might contribute to the susceptibility to BFIC. PMID: 19815358
  4. Schwann cells are the principal cellular source of Lgi4 in the developing nerve; transgenic Lgi4 binds directly to Adam22 without a requirement for additional membrane associated factors. PMID: 20220021
  5. Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. PMID: 14505228

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Involvement in disease Arthrogryposis multiplex congenita, neurogenic, with myelin defect (AMCNMY)
Subcellular Location Secreted
Tissue Specificity Widely expressed, with highest expression in brain.
Database Links

HGNC: 18712

OMIM: 608303

KEGG: hsa:163175

STRING: 9606.ENSP00000312273

UniGene: Hs.65256

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