Code | CSB-E09941h |
Size | 96T,5×96T,10×96T |
Price | Request a Quote or Start an on-line Chat |
Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now |
The ELISA Kit is designed for quantitatively measuring human PARC levels in samples, including serum, plasma, cell culture supernates, or tissue homogenates. It uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of PARC in samples. The color intensity is measured at 450 nm via a microplate reader.
PARC, also known as CCL18, is a chemokine primarily expressed in monocytes, macrophages, and immature dendritic cells and plays a crucial role in immune and inflammation responses. CCL18 attracts lymphocytes and immature dendritic cells and induces collagen deposition by fibroblasts. Recent studies have found that CCL18 is associated with the progression of malignant tumors. It is predominantly derived from breast tumor-associated macrophages (TAMs). Previous data indicate that the CCL18/Nir1 signaling promotes the invasion, metastasis, and EMT of breast cancer cells through the PI3K/Akt/GSK3β/Snail signaling pathway. CCL18 also reduces proliferation in non-small cell lung cancer cells and pre-B acute lymphocytic leukemia cells but enhances proliferation in breast cancer, diffuse large B cell lymphoma, ovarian cancer, osteosarcoma, and urothelial carcinoma.
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