Code | CSB-E04734h |
Size | 96T,5×96T,10×96T |
Price | Request a Quote or Start an on-line Chat |
Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now |
The ELISA Kit is designed for quantitatively measuring human TIMP3 levels in samples, including serum, plasma, or tissue homogenates. It uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of TIMP3 in samples. The color intensity is measured at 450 nm via a microplate reader.
TIMP3 has the broadest range of inhibition, targeting all members of the matrix metalloproteinase (MMP) family and several members of a disintegrin and metalloproteinases (ADAMs), and ADAM with thrombospondin motifs (ADAMTSs) family. Independent of its inhibitory capabilities, TIMP3 is also involved in promoting cell proliferation and regulating angiogenesis and apoptosis. The absence of TIMP3 results in poor cardiac remodeling and has been related to myocardial infarction or hypertension. In cancer studies, TIMP3 plays an important role in the cancer hallmark by controlling cell death, angiogenesis, tumor inflammation, and tumor cell invasion and dissemination.
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