Mouse Acyloxyacyl hydrolase(AOAH) ELISA kit

Instructions
Code CSB-EL001853MO
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name acyloxyacyl hydrolase (neutrophil)
Alternative Names AoahAcyloxyacyl hydrolase ELISA Kit; EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit] ELISA Kit
Abbreviation AOAH
Uniprot No. O35298
Species Mus musculus (Mouse)
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

Target Data

Function Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS)
Gene References into Functions
  1. Alveolar macrophages increase AOAH expression upon exposure to lipopolysaccharide and that Aoah+/+ mice recover more rapidly than do Aoah-/- mice from acute lung injury induced by nasally instilled lipopolysaccharide or Klebsiella pneumonia. PMID: 28622363
  2. AOAH has a role in modulating microbiota signals that drive Th17 polarization and influence mucosal T-cell immunity PMID: 24344308
  3. role in clearing and catabolizing both free LPS and the LPS in circulating LPS-lipoprotein complexes PMID: 22441700
  4. produced by renal cortical tubule cells and secreted into urine, where it can deacylate lipopolysaccharides, a mechanism to limit inflammatory response to gram-negative bacteria in urinary tract PMID: 15155618
  5. Recovery from the tolerant state induced by Gram-negative bacteria is greatly delayed in in mice that lack AOAH, a lipase that partially deacylates the bacterial cell-wall lipopolysaccharide. PMID: 18779055

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Subcellular Location Secreted, Cytoplasmic vesicle
Tissue Specificity Detected in peritoneal macrophages (at protein level) (PubMed:17322564, PubMed:28622363). Strongly expressed in kidney cortex, where it may be produced by proximal tubule cells (PubMed:15155618). In liver, expressed at high levels in Kupffer cells (PubMed
Database Links

KEGG: mmu:27052

UniGene: Mm.314046

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