Mouse Apolipoprotein O(APOO) ELISA kit

Code CSB-EL001948MO
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name apolipoprotein O
Alternative Names Apoo ELISA Kit; Fam121b ELISA Kit; Mic23 ELISA Kit; Mic26 ELISA Kit; MICOS complex subunit Mic26 ELISA Kit; Apolipoprotein O ELISA Kit; MICOS complex subunit Mic23 ELISA Kit; Protein FAM121B ELISA Kit
Abbreviation APOO
Uniprot No. Q9DCZ4
Species Mus musculus (Mouse)
Sample Types serum, plasma,tissue homogenates
Detection Range 0.625 ng/mL-40 ng/mL
Sensitivity 0.625 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Assay Principle quantitative
Measurement Competitive
and FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

Target Data

Function Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (By similarity). Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts
Gene References into Functions
  1. The liver function indices (serum ALT and AST) were clearly elevated, and the ultrastructure of cellular mitochondria was distinctly altered in the liver after apoO overexpression. Further, mitochondrial membrane potential decreased with hApoO treatment in L02 cells. PMID: 28647361
  2. APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility. PMID: 24743151
  3. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. PMID: 21296681
  4. apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein PMID: 16956892
Subcellular Location Mitochondrion inner membrane, Single-pass membrane protein, Mitochondrion, Endoplasmic reticulum membrane, Golgi apparatus membrane
Protein Families Apolipoprotein O/MICOS complex subunit Mic27 family
Database Links

KEGG: mmu:68316

STRING: 10090.ENSMUSP00000132704

UniGene: Mm.379156

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