Mouse CD70 antigen(CD70) ELISA kit

Code CSB-EL004954MO
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name CD70 molecule
Alternative Names Cd70 ELISA Kit; Cd27l ELISA Kit; Cd27lg ELISA Kit; Tnfsf7 ELISA Kit; CD70 antigen ELISA Kit; CD27 ligand ELISA Kit; CD27-L ELISA Kit; Tumor necrosis factor ligand superfamily member 7 ELISA Kit; CD antigen CD70 ELISA Kit
Abbreviation CD70
Uniprot No. O55237
Species Mus musculus (Mouse)
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Background

Function
(From Uniprot)
Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
Gene References into Functions
  1. CD70 mitigates atherosclerosis at least in part by modulating macrophage function. PMID: 27786334
  2. these findings demonstrate for the first time, to our knowledge, that T cell-derived CD70 plays a novel immune checkpoint role in inhibiting inflammatory T cell responses PMID: 29046346
  3. findings demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells. PMID: 28550198
  4. Mice lacking CD70 did not accumulate memory T cells and did not develop hypertension. PMID: 26988069
  5. find that while stimulation of CD27 in isolation drives weak Eomesodermin(hi) T-bet(lo) CD8(+) T-cell responses to OVA immunization PMID: 26461455
  6. Data show that although CD70 is required for the activation of the antiviral adaptive response, it has a regulatory role in early cytokine responses to viruses such as MCMV, possibly through maintenance of Treg survival and function. PMID: 24913981
  7. the ability of CD70 to trigger costimulation is self-regulated when it binds its complementary receptor. PMID: 23913967
  8. Expression of CD70 by B cells aggravates experimental autoimmune encephalomyelitis by reducing the number of regulatory T cells. PMID: 23137837
  9. CD70-deficient mice infected with lymphocytic choriomeningitis virus produced only half as many T8 cells. Viral clearance was substantially delayed. CD70-mediated costimulation is not required for secondary or T4 responses. PMID: 23269247
  10. Although CD70 is required for dendritic cell-mediated delay of T cell tolerance induction, CD80 and CD86 are necessary for refunctionalizing the tolerized T cells in prostate tumor tissue PMID: 22798683
  11. CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load. PMID: 22450812
  12. Adoptively transferred CD70-specific T cells induced sustained regression of established murine xenografts. PMID: 21304103
  13. In this review, CD27 and CD70 constitute a unique ligand/receptor pair which can activate innate and adaptive immunity as well as regulate immunity versus tolerance. PMID: 20699361
  14. We show here that sterile chronic immune activation driven by enhanced expression of CD70 is in fact highly protective against atherosclerosis. PMID: 20505312
  15. Data show that costimulation by CD70 or OX40L seems to be necessary for primary CD4(+) T cell responses to multiple forms of immunization. PMID: 20639485
  16. These data support the hypothesis that induction of CD70 expression on dendritic cells (DC) after an encounter with activated CD4(+) T cells is a major component of CD4(+) T cell-mediated licensing of DC. PMID: 19952354
  17. Data indicate that, while CD70 plasma membrane expression is not detectable in resting T and B cells, low levels are induced following influenza infection in lung-infiltrating activated T cells and T and B cells in draining lymph nodes. PMID: 12496380
  18. Administration of antigenic peptide and a soluble recombinant form of CD70 results in a massive (>300-fold) expansion of antigen-specific CD8+ T cells in vivo, due to the enhanced proliferation and survival of activated T cells. PMID: 15128787
  19. CD70 expression on antigen presenting cells plays a key role in CD40-dependent CD8 T cell responses; CD70 blockade inhibits CD40-mediated clonal expansion of CD8 T cells and reduces the number of memory CD8 T cells generated. PMID: 15557144
  20. Expression of CD70 on dendritic cells is an important determinant for helper-dependence of primary CD8+ T cell expansion. PMID: 15634890
  21. The novel CD70-CD27 pathway plays a critical role in alloimmune responses independently of the CD28-B7 costimulatory pathway. PMID: 15661893
  22. CD70-positive antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. PMID: 15937486
  23. ectopic expression of CD70 in mouse glioma cells enhances apoptosis of T, B and NK cells in coculture, but nevertheless promotes glioma cell lysis by NK cells in vitro PMID: 16217761
  24. innate and adaptive (CD4+ T cells) arms of the immune system use a common signaling pathway in driving CD8+ T cell responses and suggest that expression of CD70 on dendritic cell (DC) represents the hallmark of conditioned DC PMID: 16920932
  25. CD70 expression on dendritic cells plays an important role in the priming of CD8-positive T cells by pathogens. PMID: 17295392
  26. CD70 is a decision maker for Th1 differentiation by CD205(+) dendritic cells. PMID: 17438065
  27. CD27-CD27L interactions are essential for developing a robust primary antiviral CD8-positive T cell immune response. PMID: 18292513
  28. injection of alpha-galactosylceramide triggers CD70 expression on splenic T cell zone dendritic cells and that this is dependent on CD40 signaling. PMID: 18354184
  29. the sole expression of CD70 by otherwise immature cDCs sufficed to convert CD8+ T cell tolerance into immunity, defining the importance of CD27-CD70 interactions at the interface between T cell and DC. PMID: 19062317
  30. The CD27-CD70 costimulatory pathway plays an important role in the development of experimental colitis; CD70 blockade leads directly to reduction in T cell numbers and thus reduces mucosal inflammation. PMID: 19525396
  31. CD27L requires trimer stabilization and oligomerization PMID: 19596991
  32. endogenous IL-18 might facilitate stomach cancer cell immune escape by suppressing CD70 and increasing metastatic ability by upregulating CD44 and VEGF PMID: 19638429

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Subcellular Location Membrane, Single-pass type II membrane protein
Protein Families Tumor necrosis factor family
Tissue Specificity Very low level of expression. Detected in splenocytes and thymocytes.
Database Links

KEGG: mmu:21948

STRING: 10090.ENSMUSP00000019633

UniGene: Mm.42228

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