Mouse Delta-like protein 1(DLL1) ELISA kit

Instructions
Code CSB-EL006947MO
Size 96T,5×96T,10×96T
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Product Details

Target Name delta-like 1 (Drosophila)
Alternative Names Dll1Delta-like protein 1 ELISA Kit; Drosophila Delta homolog 1 ELISA Kit; Delta1) [Cleaved into: Dll1-soluble form ELISA Kit; Dll1-EC ELISA Kit; Shed form); Dll1-derived cell-associated form ELISA Kit; Dll1-TMIC ELISA Kit; Membrane-associated fragment); Dll1-intracellular form ELISA Kit; Dll1-IC)] ELISA Kit
Abbreviation DLL1
Uniprot No. Q61483
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates
Detection Range 125 pg/mL-8000 pg/mL
Sensitivity 31.25 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Developmental Biology
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 5-7 working days

Target Data

Function Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner
Gene References into Functions
  1. this study identified Notch ligand Dll1 as amarker that is enriched in mammary gland stem celsl(MaSCs) and demonstrated that Dll1+ MaSCs can generate both basal and luminal cells. PMID: 29773667
  2. Study show how delta-like protein 1 (DLK1) has a certain role in the interactions between the adipose tissue and the adenohypophyseal cells. DLK1 can directly or indirectly mediate in pituitary leptin production in growth hormone and prolactin cells. PMID: 28718206
  3. Activation of Notch signaling with the endothelial cell (EC)-targeted soluble Dll1 Notch ligand mD1R promoted bone marrow recovery after irradiation. PMID: 27188577
  4. Macrophage maturation is controlled by Notch ligand Dll1 expressed in vascular endothelial cells of arteries and requires macrophage canonical Notch signaling via Rbpj, which simultaneously suppresses an inflammatory macrophage fate. Conversely, conditional mutant mice lacking Dll1 or Rbpj show proliferation and transient accumulation of inflammatory macrophages, which antagonizes arteriogenesis and tissue repair. PMID: 29038527
  5. pre-coated Notch1 protein promotes Notch1-knocked down B cells to produce antibody in LPS-stimulated B cells suggesting that Notch1 in other cells may promote antibody production by binding its ligands Dll1 and Jag1 in B cells. PMID: 28863329
  6. Hedgehog/Patched-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells PMID: 26387541
  7. the effects of two Notch ligands, i.e., Jagged1 and DLL1, on murine and human hematopoiesis in vitro. Our observations indicate that the stromal expression of Notch ligands increases the production of both the total and phenotypically early murine and human hematopoietic cells in the co-culture. PMID: 28537242
  8. Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1. PMID: 28089369
  9. the structural integrity of each individual EGF repeat in the extracellular domain of DLL1 is necessary for full DLL1 activity PMID: 26801181
  10. Role of Dll1 in embryogenesis and notch signaling. PMID: 26114479
  11. the appropriate timing of Dll1 expression is critical for the oscillatory networks and suggest the functional significance of oscillatory cell-cell interactions in tissue morphogenesis PMID: 26728556
  12. Spatiotemporal expression oscillations of Notch1 and Dll1 are coordinated across the mouse pre-somitic mesoderm. PMID: 25468943
  13. Dll1 functions in satellite cell homing and in Pax7 expression diverge in cranial- vs. somite-derived muscle. PMID: 25220152
  14. mDLL1 O-fucosylation by POFUT1 is dispensable for ligand function PMID: 24533113
  15. suppression of IL-6, GM-CSF, and MMP-3 production by DLL-1 blockade might be responsible for the amelioration of arthritis in a mouse model of rheumatoid arthritis. PMID: 24943093
  16. Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo. PMID: 24167636
  17. A DLL1 variant in which three phosphorylated serine/threonine residues are mutated to alanine and valine, was more stable than wild-type DLL1 but had reduced relative levels on the cell surface and was more effectively cleaved in the extracellular domain. PMID: 24449764
  18. cells expressing transfected protein could support T-cell lineage differentiation PMID: 23988616
  19. The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated in the mouse testis PMID: 24015274
  20. The Notch ligand Delta-like 1 (Dll1) is required to maintain quiescent neural stem cells in the adult mouse subventricular zone. PMID: 23695674
  21. Dll1 is required for the formation of the Bergmann layer and its morphological maturation. PMID: 23688253
  22. Our finding that DLL1 is a product of immature and mature uNK cells suggests it would be profitable to explore the roles of other ILC subsets in the promotion of angiogenesis and in particular in the induction of endothelial tip cell differentiation. PMID: 23284862
  23. Delta-like 1 is involved in the differential regulation of osteoclastogenesis. PMID: 22390640
  24. Different levels of Dll1 expression determine the fate of neural precursor cells through cell-cell interactions, most likely through the Notch-Delta lateral inhibitory signaling pathway, thus contributing to the selection of differentiating cells. PMID: 18997111
  25. Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity. PMID: 19389377
  26. data suggest that the development of human B lymphocytes and HSC maintenance in osteosclerotic bone may be suppressed by introducing DLL1 PMID: 22771497
  27. We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease ( PMID: 22944320
  28. Notch1 activity in gastric cancer is controlled by the epigenetic silencing of the ligand DLL1, and that Notch1 inhibition is associated with the diffuse type of gastric cancer. PMID: 22249198
  29. MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma PMID: 21931765
  30. results suggest that Notch signaling through macrophage-dependent Dll1 is critical in providing an anti-viral response during influenza infection by linking innate and acquired immunity PMID: 22072963
  31. the presence of Gal on O-fucose glycans differentially affects DLL1-induced NOTCH signaling modulated by LFNG versus MFNG PMID: 22081605
  32. Dll1 acts as an extrinsic cue involved in tip cell selection, which directs vessel sprouting and branch formation. PMID: 22282195
  33. Data find that only secretory cells pass through a phase of strong expression of the Notch ligand Delta1. Onset of this Dll1 expression coincides with a block to further cell division and is followed by expression of Neurog3 or Gfi1. PMID: 21915337
  34. Ptf1a-induced Dll1 expression stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining Hes1 expression and Ptf1a protein levels. PMID: 22096075
  35. Anti-delta1 monoclonal antibody-treated heart transplants are a potential target in this study to improve graft-prolonging effects of Notch ligand delta1. PMID: 21949024
  36. Dll1 can promote the differentiation of DCs from mouse bone marrow cells and enhance their antigen presentation capacity. PMID: 20561433
  37. overexpression of Dll1 could activate Notch signaling in tumor cells, and promote tumor cell proliferation in vitro PMID: 21752535
  38. Elav-like (Elavl1)/HuR becomes enriched in the cytoplasm of neuroepithelial cells undergoing mitosis and that this ribonucleoprotein binds the 3' untranslated region (UTR) of Dll1 mRNA and stabilizes it. PMID: 21346194
  39. These data suggest that MT1-MMP directly cleaves Dll1 on bone marrow stromal cells to negatively regulate Notch signalling to specifically maintain normal B-cell development in bone marrow. PMID: 21572390
  40. Data suggest that selective inhibition of Notch signalling mediated by Notch3 or Delta-like1 may offer a new strategy for the treatment of RA. PMID: 21235539
  41. Notch signaling in stem cells and progenitors is activated by Dll1 and Dll4 ligands and is required for maintenance of intestinal progenitor and stem cells PMID: 21238454
  42. Results reveal that Dll1 and Jag1 are functionally equivalent in controlling the rate of neurogenesis within their expression domains. PMID: 21124801
  43. Proteolytic cleavage of Dll1 in Notch signal sending cells is dispensable for murine T-cell development, differentially affects expression of Notch target genes, and might be a mechanism that regulates myelopoiesis. PMID: 20231851
  44. Identification of miRNAs could possibly target the Dll1 3'UTR in these regions. PMID: 20558326
  45. Notch receptor(s) and Dll1 directly promote the adhesion of mast cells to stromal cells by acting as adhesion molecules. PMID: 20810995
  46. Findings show that Dll4 expressed on OP9 cells is functionally distinct from Dll1, illustrating the unique properties of Dll4 in supporting the combined T lineage and specific myeloid-lineage outcomes that underpin its function within the thymus. PMID: 20548034
  47. Notch ligands, including Delta-like1 and 3 and Jagged1 and Jagged2, show distinct expression patterns in the developing and adult brain overlapping that of Notch1 PMID: 12175503
  48. Delta-1 is essential for proper migration and differentiation of neural crest cells. Interestingly, absence of Delta-1 leads to diminution of both neurons and glia in peripheral ganglia PMID: 12217323
  49. the loss-of-function of the delta 1 (Dll1) gene causes a randomisation of the direction of heart looping and embryonic turning. The most probable cause for this defect in Dll1 mutant embryos is a failure in the development of proper midline structures PMID: 12441287
  50. identification as substrated for presenilin-dependent gamma-secretase cleavage PMID: 12551931
  51. Delta-Notch signaling controls the generation of neurons/glia from neural stem cells PMID: 12588854
  52. Dll1 is a substrate for regulated intramembrane proteolysis, and its intracellular region possibly fulfills a specific function in the nucleus PMID: 12794186
  53. Data describe the genetic interactions between Dll1, Dll3, Mesp2 and Psen1, and the roles of Dll1- and Dll3-Notch pathways, with or without Psen1, in rostrocaudal patterning. PMID: 12900443
  54. Ligation of Notch by Delta1 on splenic CD8+ cells results in a dramatic decrease in IFN-gamma with a concomitant enhancement of IL-10 production. PMID: 14660750
  55. Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration PMID: 15485825
  56. Delta 1 inhibits the differentiation of DN1 thymocytes into the B-cell lineage; Delta 1-expressing stromal cells promote the proliferation and maturation of T-cell progenitors through the early double-negative (DN) stages of thymocyte development. PMID: 15486060
  57. Delta-1 expression is sufficient to promote T cell development from the most immature progenitor stages to complete maturation of both CD8+ and CD4+ alpha beta T cells in vivo and in the absence of a thymus. PMID: 15728481
  58. Dll1 is presented on the surface of AJs formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system PMID: 15908431
  59. Genes and proteins differentially regulated in E10.5 Dll1 (delta-like 1, Delta1) mutant embryos were identified. PMID: 15979417
  60. uncovered four putative Tbx-6 binding sites within a Dll1 paraxial mesoderm enhancer PMID: 15986483
  61. DLL1, functions synergistically with JAG2 in regulating hair cell differentiation in the cochlea. PMID: 16141228
  62. Using a Cre-LoxP approach, Delta1 in the inner ear was knocked out. PMID: 16495313
  63. endogenous ADAM9 and/or ADAM12 present in wild type mouse embryonic fibroblasts contribute to Dll1 processing PMID: 17107962
  64. Dll1 provides essential signals that are required to prevent uncontrolled differentiation early and ensure sustained muscle differentiation during development. PMID: 17194759
  65. In heterozygous Dll1 mutant mice, endothelial Notch activation & ephrin-B2 induction after hindlimb ischemia were absent, arterial collateral growth was abrogated & recovery of blood flow was severely impaired, showing Dll1's role in these processes. PMID: 17234965
  66. Data show that compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints. PMID: 17572911
  67. Tbx18 interacts with Gata4 and Nkx2-5 and competes Tbx5-mediated activation of the cardiac Natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6-activated Delta-like 1 expression in the somitic mesoderm in vivo PMID: 17584735
  68. Data demonstrate distinct in vivo functions for DLL1 and DLL3, and suggest that DLL3 does not antagonize DLL1 in the presomitic mesoderm. PMID: 17664336
  69. Syntenin binding to Delta1 plays a dual role in promoting intercellular adhesion and regulating Notch signalling. PMID: 17666427
  70. Delta-like-1 engagement of Notch1 promotes differentiation of B lymphocytes to antibody-secreting cells PMID: 17878313
  71. While overall expression in the adult mouse is widespread, Dll1 may be selectively expressed in the endothelium of injured vasculature. PMID: 17898542
  72. Jagged1 may play a role in CNS homeostasis because murine astrocytes specifically express Jagged1 that is up-regulated by TGF-beta PMID: 17947672
  73. Dll1 contributes to the control of proliferation and differentiation in interfollicular epidermis, whereas Jagged1 regulates hair follicle differentiation. PMID: 17960184
  74. Delta-like 1 increases dopamine progenitor cell proliferation in ventral midbrain. PMID: 17986227
  75. Expression of Delta1 or Delta4 by dendritic cells enhanced their ability to activate naive Th cells and promote Th1 cell development, and allowed them to strongly inhibit Th2 cell development. PMID: 18209061
  76. The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PMID: 18676613
  77. distinct functional properties for the Notch ligands Jagged1 and Delta1 in the promotion of tumorigenicity in vivo. PMID: 18688026
  78. the expression of Dll1 in splenic non-hematopoietic stromal cells, but not hematopoietic cells, is essential for the development of marginal zone B cells. PMID: 18786568
  79. DLL1 regulated the cell differentiation and self-renewal of muscle cell. PMID: 18957511
  80. Dll1/Notch1,2 signaling confers the functions as an antigen-presenting cell on mast cells, which preferentially induce the differentiation of T(H)2. PMID: 19130928
  81. DLL1 is a critical endothelial Notch ligand required for maintaining arterial identity during mouse fetal development. PMID: 19144989
  82. mAb blocking results in reduced numbers of marginal zone B cells in the spleen with no effect on follicular Dendritic cells PMID: 19181931
  83. Dll1 are expressed in the developing mouse eye and in retinal progenitor cell. PMID: 19191219
  84. Lunatic Fringe (Lfng) and Manic Fringe (Mfng) cooperatively enhanced the DL1-Notch2 interaction to promote marginal zone B cell development PMID: 19217325
  85. Results demonstrated that 70-75% of the fibroblasts generated from Dll1-msd Cre, ROSA26-rtTA embryos possess Cre recombinase activity. PMID: 19298012
  86. Dll1 has a role in metabolic and immunological processes PMID: 19562077

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Subcellular Location Apical cell membrane, Single-pass type I membrane protein, Cell junction, adherens junction, Membrane raft
Tissue Specificity In the embryo, expressed in the paraxial mesoderm and nervous system. Expressed at high levels in adult heart and at lower levels, in adult lung. Highly expressed in satellite cells from masseter and tongue than in satellite cells from leg and extraocular
Database Links

KEGG: mmu:13388

STRING: 10090.ENSMUSP00000014917

UniGene: Mm.4875

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