Mouse Interleukin-12 subunit alpha(IL12A) ELISA kit

1. IL-12 receptor signalling in keratinocytes initiates a protective transcriptional programme that limits skin inflammation. PMID: 27892456
2. The authors found that the expressions of the mRNAs of both IL-12p35 and IL-12p40 were significantly reduced in the oxygen-induced retinopathy retinas compared to that of the room air-raised control. The results suggest that IL-12 plays important roles in inhibiting pathological retinal neovascularization. PMID: 27312090
3. IL-35-transduced adipocyte-derived mesenchymal stem cells in vivo can enhance proliferation of CD4(+) CD25(+) Treg cells and suppress the function of effector T cells such as T helper (Th) 1, Th2 and Th17 cells and may reduce the development of allograft rejection. PMID: 28888053
4. findings show that IL-12 and other proinflammatory cytokines transduce signals through the TCR signalosome in a manner that requires Fyn activity and self-peptide-MHC (self-pMHC) interactions. PMID: 27521342
5. this study shows that a systemic IL-12 primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis PMID: 27891587
6. These results suggest a correlation between CRMP2 phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta accumulation stage in AD model mice. PMID: 27059136
7. Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines. PMID: 27460435
8. Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia. PMID: 26844658
9. Deficiency of IL-12p35 limited AMI-induced cardiac injury by promoting pro-angiogenesis and anti-inflammatory functions of monocytes PMID: 26614777
10. IL-12 immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer. PMID: 26430781
11. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet. PMID: 26950239
12. Irradiation-induced IL-6 can decrease IL-12 production through the inhibition of C-Rel phosphorylation by the IL-6/STAT3 signaling pathway. PMID: 26745884
13. The IL-12 response by dendritic cells against S. aureus is highly growth phase dependent. PMID: 26872029
14. These results provide a new pathway of Th1 response regulation where IL-12 secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells. PMID: 26745371
15. These findings reveal previously unappreciated roles for IL-35 in limiting anti-tumor immunity and contributing to T cell dysfunction in the tumor microenvironment. PMID: 26872697
16. IL-12p35 has a protective role against pulmonary infection with methicillin-resistant Staphylococcus aureus. PMID: 26248370
17. TBI-induced IL12 augments Tc17 cell-mediated tumor immunity and underline the substantial implications of in vitro preparation of antitumor Tc17 cells with IL12 in the design of T-cell immunotherapies PMID: 25904754
18. Interleukin-12-producing CD103+ CD11b- CD8+ dendritic cells are responsible for eliciting gut intraepithelial lymphocyte response against Encephalitozoon cuniculi. PMID: 26416905
19. Interferon-gamma (IFN-gamma) and interleukin-12 (IL-12) levels in the tumors and plasma were significantly enhanced after processing with recombinant mouse CCL19. PMID: 25661385
20. IL-35 subunits (p35 and EBI3) have the immunoregulatory role in systemic lupus erythematosus. PMID: 25845911
21. Taken together, IL32gamma will be useful as an adjuvant to boost the cytotoxicities of NK and NKT cells that play critical roles in antitumor immunity. PMID: 25858316
22. These findings reveal a critical role for IL-12 in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment. PMID: 25762781
23. Results suggest that p35 helps in maintaining the testicular immune privilege, in part in an IL-35-dependent manner. PMID: 24760014
24. IL-35 mitigates murine acute graft-versus-host disease with retention of graft-versus-leukemia effects. PMID: 25363669
25. IL-12 production by Batf3-dependent CD103+ dendritic cells is crucial for maintenance of local Th1 immunity against L. major infection. PMID: 25312824
26. Data (including data from knockout mice) suggest Ebi3 (Epstein-Barr virus induced protein 3) and Il12a (interleukin-12 subunit p35) down-regulate helper-inducer T-lymphocyte (Th17 cell) function in immune response to Listeria monocytogenes. PMID: 24068935
27. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. [il-35] PMID: 24743305
28. Dap12- and FcRgamma-deficiency exacerbates Granulocyte-Macrophage Colony-Stimulating Factor-driven monocyte differentiation and production of inflammatory monocyte-derived dendritic cells. PMID: 24155889
29. Data indicate that while diminishing IL-12 and IL-23 secretion, sphingosine-1-phosphate (S1P) enhanced IL-27 production in dendritic cells (DCs). PMID: 24434636
30. Whereas both IL-12/Th1 and IL-23/Th17 are involved in cholangitis, it is the IL-12/Th1 signaling pathway that elicits pathology. PMID: 24040208
31. knockout of p35 in a transgenic Alzheimer mouse model leads to higher mortality rates and exhibited impaired spatial learning and memory at 6 months of age. Also a a reduction in the expression of synaptic markers such as NMDAR1, synaptophysin and GluR1. PMID: 23905994
32. IL-12a induces the expression of IL-7 in microglia and macrophages via both IL-12Rbeta2 and IL-12Rbeta1. PMID: 24224652
33. IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo. PMID: 24367005
34. C5a regulates IL-12(+)dendritic cell migration to induce pathogenic Th1 and Th17 cells in sepsis. PMID: 23936099
35. Cdk5 and p35 are expressed in a murine odontoblast-enriched primary preparation of cells from teeth PMID: 23668392
36. Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-beta abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice, and suggest combined role of mast cells and Tregs. PMID: 24142033
37. Liver sinusoidal endothelial cells undergo immunological maturation exclusively in response to TLR1/2 ligand stimulation. This is achieved by regulating the balance between PD-L1 & IL-12 expression. PMID: 24227786
38. These data indicate that IL-12 has a nonprotective role in the acute phase and that IL-12 deficiency results in the accelerated formation of a protective capsule during the healing phase, which is considered crucial for early recovery from disease. PMID: 23532102
39. IL-12 and IFN-alpha differentially program CD8 T cells to re-express distinct levels of PD-1 upon re-encountering Ag, resulting in IL-12-stimulated cells being less susceptible to exhaustion in the face of sustained tumor Ag. PMID: 23804712
40. IL-12 and IL-2 enhance the IFN-gamma expression reduce the colony load and increase the survival rate in invasive pulmonary aspergillosis mouse model. PMID: 22834482
41. Data indicate that NK1R-dendritic cells (DCs) promote cellular immunity that requires IL-12p70. PMID: 23365459
42. The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production. PMID: 23297419
43. The expansion of CD8 T cells depends on type I IFN, type I IFN and IL-12 or is largely independent of the two cytokines. PMID: 22815848
44. WISP-1 exerts paracrine action on immune cells by inhibiting their response to IL12 PMID: 22777646
45. neither IL-12p40 nor IL-12p35 molecules are required for prion disease-associated neurodegeneration or neuroinflammation PMID: 22787236
46. Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2 PMID: 22710123
47. Deficiency in interleukin-12p35 regulates angiotensin II-induced cardiac fibrosis by promoting CD4(+) T-cell-dependent differentiation of M2 macrophages and production of transforming growth factor-beta. PMID: 22556333
48. Systemic IL-12 administration alters hepatic dendritic cell stimulation capabilities. PMID: 22428016
49. IL-35 production by inducible costimulator-positive Treg cells can suppress IL-17 production and thereby reverse established, IL-17-dependent airway hyperresponsiveness in mice. PMID: 21906794
50. Gene silencing of IL-12 in dendritic cells was shown to selectively inhibit T cell proliferation on recall responses. PMID: 22289162

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KEGG: mmu:16159

STRING: 10090.ENSMUSP00000029345

UniGene: Mm.103783