Mouse Leucine-rich glioma-inactivated protein 1(LGI1) ELISA kit

Instructions
Code CSB-EL012898MO
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name leucine-rich, glioma inactivated 1
Alternative Names Lgi1Leucine-rich glioma-inactivated protein 1 ELISA Kit
Abbreviation LGI1
Uniprot No. Q9JIA1
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates
Detection Range 31.25 pg/mL-2000 pg/mL
Sensitivity 7.81 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Neuroscience
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Data

Function Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity).
Gene References into Functions
  1. LGI1 is expressed at the axonal initial segment and regulates action potential firing by setting the density of the axonal Kv1.1 channels. PMID: 28673977
  2. LGI1 has a role in regulating cortical development, which is increasingly becoming recognized as one of the causes of idiopathic epilepsy. PMID: 25346110
  3. LGI1 and ADAM22 form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95 PMID: 26178195
  4. Review article demonstrating that LGI1 may be an essential player in the development of the brain PMID: 25471260
  5. Glutamatergic neuron-targeted loss of Lgi1 causes a severe epileptic phenotype; Lgi1 displays an essential role in brain during the whole life. PMID: 25234641
  6. Lgi1 contains nuclear localization signal that mediates Lgi1 localization to cytoplasm and nucleus in CNS embryonic neurons. PMID: 22612501
  7. This study demonistrated that LGI1 plays a critical role in both dendritic and axonal pruning, we identify a novel molecular pathway in synapse and circuit remodeling. PMID: 22262888
  8. Lgi1 may have a role in establishing normal brain architecture and neuronal functions during brain development suggesting that it may be involved in neurogenesis and neuronal plasticity PMID: 21569517
  9. LGI1(+/-) and LGI1(-/-) mice may provide useful models for lateral temporal lobe epilepsy, and more generally idiopathic focal epilepsy. PMID: 20659958
  10. Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability. PMID: 20130004
  11. in the brain of C57BL/6J adult mice by in situ hybridization. We found that the LGI1 transcript is mainly expressed in the dentate gyrus and CA3 field of the hippocampus. PMID: 19833108
  12. Reduce levels of secreted LGI1 is associated with autosomal dominant partial epilepsy with auditory features PMID: 15857855
  13. Two protein isoforms encoded by LGI1/epitempin are differentially expressed in mouse brain: the 60-kDa form is detected in the microsomal fraction, while the 65-kDa product is found in the cytosolic fraction. PMID: 16787412
  14. This study was the first to determine a specific profile of Lgi1 gene expression during central nervous system development, which suggests a possible inhibitory function in latter stages of development. PMID: 18563303
  15. study identified LGI1 as a specific binding partner of ADAM22 protein from mouse brain, and demonstrated the specific interaction between LGI1 and ADAM22 PMID: 18974846
  16. The normal postnatal maturation of presynaptric and postsynaptic functions was arrested by the 835delC mutant Lgi1. PMID: 19701204

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Subcellular Location Secreted, Cell junction, synapse
Tissue Specificity Brain.
Database Links

KEGG: mmu:56839

STRING: 10090.ENSMUSP00000084507

UniGene: Mm.298251

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