Mouse Neuropeptide S(NPS) ELISA kit

Instructions
Code CSB-EL016026MO
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name neuropeptide S
Alternative Names Nps ELISA Kit; Neuropeptide S ELISA Kit
Abbreviation NPS
Uniprot No. P0C0P8
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates
Detection Range 4.69 pg/mL-300 pg/mL
Sensitivity 1.17 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Biochemicals
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

Target Data

Function May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.
Gene References into Functions
  1. Study showed that the actions of neuropeptide S influenced the excitability of dorsal raphe and laterodorsal tegmentum neurons, which could play a role in the anxiolytic and arousal-promoting effects of this peptide. PMID: 28655610
  2. NPS-/- mice display significant deficits in exploratory activity, long-term memory and arousal. PMID: 28548278
  3. these results indicate that NPS-NPSR system may regulate locomotion together with the CRF1 system in SN. PMID: 26239581
  4. These data provide evidence for a direct interaction between the corticotropin-releasing factor and the NPS system and thereby extend previous observations of NPS-modulated stress responsiveness towards a mechanistic level. PMID: 22570383
  5. Neuropeptide S knock-out mice display deficits in inhibitory avoidance memory indicating involvement in central noradrenergic systems. PMID: 21150909
  6. Results describe the neuroanatomical, molecular, and functional aspects of neuropeptide S-producing neurons in the mouse brain. PMID: 21452230
  7. These data demonstrate that the distribution pattern of the central neuropeptide S system is only partially conserved between mice and rats. PMID: 21452235
  8. results demonstrate that neuropeptide S and NPSR1 regulate respiratory function through a central nervous system-mediated pathway PMID: 21167892
  9. Data suggest that lithium evokes antagonistic effects on the mediation of hyperlocomotion and protection against lipid peroxidation induced by neuropeptide S. PMID: 19616051
  10. analysis of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus PMID: 18628994
  11. NPS facilitates spatial memory and mitigates MK801-induced spatial memory impairment in mice. PMID: 19429110

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Subcellular Location Secreted
Database Links

KEGG: mmu:100043254

STRING: 10090.ENSMUSP00000095597

UniGene: Mm.192092

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