Mouse Soluble protein-100,S-100 ELISA Kit

Instructions
Code CSB-E08068m
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name S100 calcium binding protein A1
Alternative Names S100a1Protein S100-A1 ELISA kit; S-100 protein alpha chain ELISA kit; S-100 protein subunit alpha ELISA kit; S100 calcium-binding protein A1 ELISA kit
Abbreviation S100A1
Uniprot No. P56565
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates
Detection Range 3.12 ng/mL-200 ng/mL
Sensitivity 0.78 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Data

Function Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity.
Gene References into Functions
  1. S100A1-KO exhibited increased right ventricular (RV) weight and elevated RV pressure in the absence of altered left ventricular filling pressures, increase in wall thickness of muscularized pulmonary arteries and a reduction in microvascular perfusion. PMID: 25395393
  2. S100A1 and S100B are dispensable for endochondral ossification during skeletal development. PMID: 25152033
  3. S100A1 ablationalso reduced plaque associated and increased non-plaque associated PO4-Akt and PO4-GSK3beta staining. PMID: 24931125
  4. Patients with acute myocardial infarction (MI) showed significantly increased S100A1 serum levels. Experimental MI in mice induced comparable S100A1 release. S100A1 signaling in cardiac fibroblasts occurs through endosomal TLR4/MyD88. PMID: 24833748
  5. hypoxia-induced MiR-138 is an essential mediator of EC dysfunction via its ability to target the 3'UTR of S100A1. PMID: 24244340
  6. Data suggest that the absence of S100A1 suppresses physiological AP-induced Ca(2+) release flux, resulting in impaired contractile activation and force production in skeletal muscle. PMID: 20686070
  7. Chronic absence of S100A1 results in enhanced L-type Ca2+ channel activity combined with a blunted sarcoplasmic reticulum Ca2+ release amplification. PMID: 20097960
  8. may serve as an endogenous enhancer of sarcoplasmic reticulum Ca2+ release and might therefore be of physiological relevance in the process of excitation-contraction coupling in skeletal muscle PMID: 12721284
  9. S100A1 plays an important in vivo role in the regulation of cardiac function perhaps through interacting with the ryanodine receptor PMID: 12777394
  10. study provides evidence that downregulation of S100A1 protein critically contributes to contractile dysfunction of the diseased heart, which is potentially responsible for driving the progressive downhill clinical course to postischemic heart failure PMID: 16952982
  11. S100A1 plays a role in modulating innate fear and exploration of novel stimuli. PMID: 17045663
  12. Ca(2+)-dependent interaction of S100A1 with Atpaf1 leads to an increased ATP content in cardiomyocytes. PMID: 17438143
  13. Endothelial S100A1 modulates vascular function because lack of S100A1 expression leads to decreased endothelial NO release, which contributes to impaired endothelium-dependent vascular relaxation and hypertension in SKO mice. PMID: 18292599
  14. S100A1 deficiency results in cardiac repolarization delay and alternating ventricular conduction defects in response to sympathetic activation accompanied by a significantly different transcriptional regulation. PMID: 18645228
  15. Data show that S100 appears in the inner ear later (E14) and is connected with the development of the supporting cells. PMID: 19226521
  16. Lack of S100A1 in mice confers a gender-dependent hypertensive phenotype and increased mortality after myocardial infarction. PMID: 19286962
  17. Our findings are consistent with similar activation kinetics for SR Ca(2+) channels in both WT and KO fibres, but decreased Ca(2+) release in the KO fibres possibly due to shorter SR channel open times. PMID: 19651766

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Subcellular Location Cytoplasm
Protein Families S-100 family
Database Links

KEGG: mmu:20193

STRING: 10090.ENSMUSP00000058237

UniGene: Mm.24662

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